Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

ras GENES

1987 • 3,818 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

1985 • 272 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

Use of the silkworm, Bombyx mori, and an insect baculovirus vector for high-level expression and secretion of biologically active mouse interleukin-3

1987 • 167 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

1988 • 152 citations

Identification of a nucleotide exchange-promoting activity for p21ras.

1990 • 144 citations

Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.

1989 • 136 citations

Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines.

1987 • 129 citations

Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.

1986 • 123 citations

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins

1990 • 119 citations

Expression of murine and human granulocyte-macrophage colony-stimulating factors in S. cerevisiae: mutagenesis of the potential glycosylation sites.

1986 • 105 citations

Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.

1988 • 104 citations

Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.

1989 • 102 citations

Induction of Neurite Formation in PC12 Cells by Microinjection of Proto-Oncogenic Ha-ras Protein Preincubated with Guanosine-5′-O-(3-Thiotriphosphate)

1987 • 95 citations

The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1.

1987 • 91 citations

Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins.

1990 • 73 citations

Reversible abrogation of IL-3 dependence by an inducible H-ras oncogene.

1989 • 48 citations

Effect of infection with murine recombinant retroviruses containing the v-src oncogene on interleukin 2- and interleukin 3-dependent growth states.

1987 • 47 citations

Abelson Virus Abrogation of Interleukin-3 Dependence in a Lymphoid Cell Line

1986 • 46 citations

Infection of immune mast cells by Harvey sarcoma virus: immortalization without loss of requirement for interleukin-3.

1985 • 46 citations

Analysis of guanine nucleotide bound to ras protein in PC12 cells

1988 • 41 citations

Colony-stimulating factor (CSF) controls proliferation of CSF-dependent cells by acting during the G1 phase of the cell cycle.

1984 • 38 citations

Interactions of Phosphatidylinositol Kinase, GTPase-Activating Protein (GAP), and GAP-Associated Proteins with the Colony-Stimulating Factor 1 Receptor

1990 • 38 citations

Expression of interleukin 2 receptors on interleukin 3-dependent cell lines.

1986 • 38 citations

A v-H-ras-Dependent Hemopoietic Tumor Model Involving Progression from a Clonal Stage of Transformation Competence to Autocrine Interleukin 3 Production

1989 • 37 citations

Hematopoietic Growth Factors Activate the Tyrosine Phosphorylation of Distinct Sets of Proteins in Interleukin-3-Dependent Murine Cell Lines

1988 • 35 citations

EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor.

1989 • 30 citations

Tyrosine Kinase Oncogenes Abrogate Interleukin-3 Dependence of Murine Myeloid Cells through Signaling Pathways Involving c-myc: Conditional Regulation of c-myc Transcription by Temperature-Sensitive v-abl

1989 • 28 citations

The v-fms Oncogene Induces Factor-Independent Growth and Transformation of the Interleukin-3-Dependent Myeloid Cell Line FDC-P1

1987 • 19 citations

Infection of Immune Mast Cells by Harvey Sarcoma Virus: Immortalization Without Loss of Requirement for Interleukin-3

1985 • 17 citations