Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

1996 • 1,158 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Structure and mechanism of DNA topoisomerase II

1996 • 844 citations

Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia

1991 • 723 citations

An STS-Based Radiation Hybrid Map of the Human Genome

1997 • 323 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 319 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide.

1993 • 269 citations

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1996 • 242 citations

ALL-1 partial duplication in acute leukemia.

1994 • 219 citations

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter]

1991 • 210 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11.

1996 • 193 citations

Alu: Structure, Origin, Evolution, Significance, and Function of One-Tenth of Human DNA

1996 • 190 citations

ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

1994 • 167 citations

ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children

1995 • 137 citations

Myeloid neoplasia in children treated for solid tumours

1990 • 108 citations

Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.

1995 • 107 citations

Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

1990 • 94 citations

Complete exon structure of the ALL1 gene.

1996 • 68 citations

Radiotherapy- and chemotherapy-induced myelodysplasia and acute myeloid leukemia. A review

1992 • 68 citations

MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes.

1997 • 65 citations

MLL tandem duplication and multiple splicing in adult acute myeloid leukemia with normal karyotype.

1996 • 61 citations

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome

1997 • 55 citations

Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.

1993 • 46 citations

Genome walking with 2- to 4-kb steps using panhandle PCR.

1993 • 39 citations

Tandem duplication of theMLL gene in myelodysplastic syndrome-derived overt leukemia with trisomy 11

1997 • 23 citations

Panhandle PCR.

1995 • 7 citations