Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo.

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Mechanism of multidrug resistance

1988 • 630 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases

1981 • 231 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

DNA topoisomerases as targets for cancer therapy

1985 • 197 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

1991 • 149 citations

Rapid detection and isolation of covalent DNA/protein complexes: application to topoisomerase I and II.

1984 • 141 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

Tumour cell resistance to anthracyclines ? A review

1985 • 120 citations

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1992 • 94 citations

The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.

1990 • 84 citations

Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.

1991 • 78 citations

Pharmacology and Clinical Toxicity of 4'-Iodo-4'-deoxydoxorubicin: An Example of Successful Application of Pharmacokinetics to Dose Escalation in Phase I Trials

1990 • 73 citations

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.

1987 • 73 citations

Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors

1990 • 70 citations

Markedly reduced levels of anthracycline-induced DNA strand breaks in resistant P388 leukemia cells and isolated nuclei.

1987 • 59 citations

Pharmacokinetics of 4'-deoxy-4'-iodo-doxorubicin in plasma and tissues of tumor-bearing mice compared with doxorubicin.

1987 • 39 citations

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration.

1988 • 32 citations

Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells

1990 • 28 citations

Drug Accumulation and Binding in P-Glycoprotein-Associated Multidrug Resistance

1991 • 14 citations

In vitro studies on anthracycline haloderivatives.

1986 • 6 citations