The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics

1985 • 331 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Translocations, master genes, and differences between the origins of acute and chronic leukemias

1991 • 286 citations

Role of chromosome translocations in human neoplasia

1987 • 226 citations

Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines

1987 • 218 citations

Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

1986 • 204 citations

Activation of the c-myc gene by translocation: a model for translational control.

1983 • 196 citations

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

1990 • 196 citations

Mosaic structure of globular domains in the human type VI collagen alpha 3 chain: similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors.

1990 • 189 citations

Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.

1991 • 185 citations

Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines

1987 • 175 citations

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

1986 • 160 citations

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

1992 • 109 citations

The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.

1990 • 107 citations

Interactions of thePolycomb group of genes with homeotic loci ofDrosophila

1991 • 101 citations

Genes involved in the activation of the bithorax complex ofDrosophila

1981 • 84 citations

Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line

1991 • 64 citations

Genetic Control of the Spatial Pattern of Selector Gene Expression in Drosophila

1985 • 54 citations

An altered 11-kilobase transcript in leukemic cell lines with the t(4;11)(q21;q23) chromosome translocation.

1992 • 53 citations

Gene order, amplification, and rearrangement of chromosome band 11q23 in hematologic malignancies

1989 • 48 citations

Immunoglobulin gene rearrangements and expression in diffuse histiocytic lymphomas reveal cellular lineage, molecular defects, and sites of chromosomal translocation

1986 • 38 citations

Cloning and molecular characterization of the trithorax locus of Drosophila melanogaster.

1989 • 38 citations

In vitro culture of leukemic cells in t(4;11) acute leukemia

1985 • 34 citations

Mapping studies and expression of genes located on human chromosome 11, band q23

1988 • 33 citations

Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus

1990 • 33 citations