The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1993 • 3,564 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

RGS Proteins and Signaling by Heterotrimeric G Proteins

1997 • 522 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1992 • 399 citations

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

1990 • 395 citations

Differential regulation of rasGAP and neurofibromatosis gene product activities

1991 • 338 citations

Aluminofluoride and beryllofluoride complexes: new phosphate analogs in enzymology

1990 • 307 citations

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

1995 • 273 citations

Solution Structure and Dynamics of Ras p21.cntdot.GDP Determined by Heteronuclear Three- and Four-Dimensional NMR Spectroscopy

1994 • 271 citations

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

1992 • 268 citations

Purification of ras GTPase activating protein from bovine brain.

1988 • 255 citations

Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.

1984 • 235 citations

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.

1996 • 205 citations

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1996 • 201 citations

The effector interactions of p21ras

1993 • 193 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

1996 • 172 citations

How ras-related proteins talk to their effectors

1996 • 162 citations

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

1992 • 132 citations

AlF ₃ mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

1997 • 117 citations

Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras.

1993 • 104 citations

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

1993 • 96 citations

Is there a rate-limiting step before GTP cleavage by H-ras p21?

1991 • 84 citations

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras

1993 • 78 citations

Aluminium fluoride associates with the small guanine nucleotide binding proteins

1997 • 72 citations

The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.

1991 • 69 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Asparagine 26, glutamic acid 31, valine 45, and tyrosine 64 of Ras proteins are required for their oncogenicity.

1992 • 54 citations

Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.

1992 • 54 citations

Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2^Val-19-activated phenotypes

1994 • 33 citations

Mechanism of Inhibition by Arachidonic Acid of the Catalytic Activity of Ras GTPase-activating Proteins

1996 • 33 citations

Identification of Neurofibromin Mutants That Exhibit Allele Specificity or Increased Ras Affinity Resulting in Suppression of Activated ras Alleles

1996 • 32 citations

Characterization of Ras effector mutant interactions with the NF1-GAP related domain.

1993 • 24 citations

Determinants of Ras proteins specifying the sensitivity to yeast Ira2p and human p120-GAP.

1996 • 19 citations

Télévision soviétique (1989-1990)

1990 • 1 citations