Persistence of the AML1/ETO fusion transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1994 • 4,563 citations

Avoiding false positives with PCR

1989 • 3,564 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes

1988 • 563 citations

Induction of Graft-versus-Host Disease as Immunotherapy for Relapsed Chronic Myeloid Leukemia

1994 • 510 citations

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

1993 • 484 citations

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

1995 • 391 citations

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission

1993 • 297 citations

Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation

1991 • 288 citations

Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children [see comments]

1992 • 194 citations

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

1993 • 193 citations

Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34

1992 • 178 citations

An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation

1993 • 174 citations

AML1/ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation.

1994 • 156 citations

Associations between morphology, karyotype, and clinical features in myeloid leukemias

1987 • 154 citations

Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction

1993 • 139 citations

Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.

1994 • 100 citations

Correlation between cell morphology and expression of the AML1/ETO chimeric transcript in patients with acute myeloid leukemia without the t(8;21).

1994 • 85 citations

Leukemia-associated changes identified by quantitative flow cytometry. IV. CD34 overexpression in acute myelogenous leukemia M2 with t(8;21)

1996 • 82 citations

Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia.

1991 • 70 citations

Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.

1992 • 70 citations

Disappearance of AML1 ‐MTG8(ETO) fusion transcript in acute myeloid leukaemia patients with t(8;21) in long‐term remission

1995 • 60 citations

Use of the polymerase chain reaction in the detection of AML1/ETO fusion transcript in t(8;21)

1995 • 51 citations

Quantitative analysis of AML1/ET0 transcripts in peripheral blood stem cell harvests from patients with t(8;21) acute myelogenous leukaemia

1995 • 49 citations

Detection of t(8;21) by reverse transcriptase polymerase chain reaction in patients in remission of acute myeloid leukaemia type M2 after chemotherapy or bone marrow transplantation

1994 • 48 citations

Distinct patterns of minimal residual disease associated with graft-versus-host disease after allogeneic bone marrow transplantation for chronic myelogenous leukemia.

1995 • 44 citations

Description of an efficient and highly informative method for the evaluation of hematopoietic chimerism following allogeneic bone marrow transplantation.

1995 • 38 citations

Identical fusion transcript associated with different breakpoints in the AML1 gene in simple and variant t(8;21) acute myeloid leukemia.

1995 • 34 citations

Polyclonal haemopoieses associated with long‐term persistence of the AML1‐ETO transcript in patients with FAB M2 acute myeloid leukaemia in continous clinical remission

1995 • 26 citations

Transverse Leukonychia

1995 • 10 citations

Molecular analysis of 12 patients with the t(8;2l) translocation and M2 acute myelogenous leukemia

1992 • 6 citations