Panhandle Polymerase Chain Reaction Amplifies MLL Genomic Translocation Breakpoint Involving Unknown Partner Gene

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

An STS-Based Radiation Hybrid Map of the Human Genome

1997 • 323 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 284 citations

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

1993 • 260 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 236 citations

Biology and treatment of infant leukemias.

1995 • 231 citations

Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group.

1989 • 227 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 223 citations

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

1994 • 223 citations

Identification of a new, abundant superfamily of mammalian LTR-transposons

1993 • 223 citations

Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children's Cancer Group

1996 • 222 citations

Alu: Structure, Origin, Evolution, Significance, and Function of One-Tenth of Human DNA

1996 • 190 citations

Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the childrens cancer study group)

1989 • 189 citations

Chromosome analysis by non-isotopic in situ hybridization.

1992 • 172 citations

A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia

1995 • 169 citations

Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

1994 • 155 citations

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1994 • 149 citations

ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children

1995 • 137 citations

A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells

1995 • 136 citations

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

1994 • 132 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 115 citations

A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

1994 • 111 citations

Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group.

1993 • 102 citations

A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities

1994 • 97 citations

Sequence specific generation of a DNA panhardle permits PCR amplication of unknown flanking DNA

1992 • 95 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 95 citations

Molecular analysis of infant acute lymphoblastic leukemia: MLL gene rearrangement and reverse transcriptase-polymerase chain reaction for t(4; 11)(q21; q23)

1995 • 74 citations

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome

1997 • 55 citations

Detection of 11q23/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis.

1995 • 44 citations

Genome walking with 2- to 4-kb steps using panhandle PCR.

1993 • 39 citations