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Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

Data up to Jan 2025

Published2000
Citations978
References195

Total Citations Per Year

Abstract

References (195)

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Oxidative Stress Inhibits Apoptosis in Human Lymphoma Cells

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A necessary role for cell shrinkage in apoptosis

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A Direct Interaction between the Aryl Hydrocarbon Receptor and Retinoblastoma Protein

1998 • 249 citations

NF-κB activation

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Oxidative Inactivation of Cytochrome P-450 1A (CYP1A) Stimulated by 3,3′,4,4′-Tetrachlorobiphenyl: Production of Reactive Oxygen by Vertebrate CYP1As

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Adverse Reproductive Outcomes in the Transgenic Ah Receptor-Deficient Mouse

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Down-regulation of Cytochrome P450 1A1 Gene Promoter by Oxidative Stress

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NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase.

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A quantitative test for superoxide radicals produced in biological systems

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Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

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Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

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I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.

1992 • 167 citations

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

1982 • 160 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.

1993 • 160 citations

Dioxin Causes a Sustained Oxidative Stress Response in the Mouse

1998 • 159 citations

Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction.

1994 • 158 citations

The Involvement of Aryl Hydrocarbon Receptor in the Activation of Transforming Growth Factor-β and Apoptosis

1998 • 154 citations

Targeting of NH2-terminal–processed Microsomal Protein to Mitochondria: A Novel Pathway for the Biogenesis of Hepatic Mitochondrial P450MT2

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Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

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The Gut-enriched Krüppel-like Factor Suppresses the Activity of the CYP1A1 Promoter in an Sp1-dependent Fashion

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Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress.

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The Mutagenicity of the Tyrosine Metabolite, Fumarylacetoacetate, Is Enhanced by Glutathione Depletion

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Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization

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Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.

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Cytochrome P450IA1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics.

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Activation of transcription factors activator protein-1 and nuclear factor-κB by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

2000 • 107 citations

Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice

1993 • 105 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Induction

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A role for phosphorylation and degradation in the control of NF-κB activity

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Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2

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Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway.

1994 • 89 citations

Toward a Molecular Basis of Alcohol Use and Abuse

1994 • 89 citations

Piperonyl butoxide and acenaphthylene induce cytochrome P450 1A2 and 1B1 mRNA in aromatic hydrocarbon-responsive receptor knock-out mouse liver.

1996 • 88 citations

Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced oxidative stress in female rats

1990 • 82 citations

Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.

1995 • 80 citations

Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors

1998 • 77 citations

A Benzo[a]pyrene-induced Cell Cycle Checkpoint Resulting in p53-independent G1 Arrest in 3T3 Fibroblasts

1997 • 77 citations

Effect of Transforming Growth Factor-β1on Expression of Aryl Hydrocarbon Receptor and Genes ofAhGene Battery: Clues for Independent Down-Regulation in A549 Cells

1997 • 74 citations

Rescue of mice homozygous for lethal albino deletions: implications for an animal model for the human liver disease tyrosinemia type 1.

1993 • 73 citations

Induction of Drug-Metabolizing Enzymes by Dioxin

1997 • 72 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants.

1993 • 72 citations

Regulation of the CYP1A1 promoter in transgenic mice: an exquisitely sensitive on-off system for cell specific gene regulation

1996 • 71 citations

The Ah Receptor Is Not Involved in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated Apoptosis in Human Leukemic T Cell Lines

1998 • 71 citations

Leukocyte Activation Induces Aryl Hydrocarbon Receptor Up-Regulation, DNA Binding, and IncreasedCyp1a1Expression in the Absence of Exogenous Ligand

1997 • 71 citations

RT-PCR quantification of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p- dioxin and hydrocortisone

1999 • 70 citations

Evidence That Murine Preimplantation Embryos Express Aryl Hydrocarbon Receptor

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Biochemical mechanisms of cytotoxicity

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Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus.

1992 • 66 citations

The Ah receptor: Binding specificity only for foreign chemicals?

1984 • 65 citations

Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression

1995 • 64 citations

Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene

1993 • 62 citations

Complete Rescue of Lethal Albino c Mice by Null Mutation of 4-Hydroxyphenylpyruvate Dioxygenase and Induction of Apoptosis of Hepatocytes in These Mice by in VivoRetrieval of the Tyrosine Catabolic Pathway

1997 • 61 citations

AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture

1999 • 59 citations

The MurineCyp1a-1Gene Negatively Regulates Its Own Transcription and that of Other Members of the Aromatic Hydrocarbon-Responsive [Ah] Gene Battery

1990 • 59 citations

Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats

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Damage to DNA by UV light and activation of transcription factors

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Aryl Hydrocarbon Receptor Regulation of Ceramide-induced Apoptosis in Murine Hepatoma 1c1c7 Cells

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Differences in Inducibility of CYP1A1-mRNA by Benzimidazole Compounds between Human and Mouse Cells: Evidences of a Human-Specific Signal Transduction Pathway forCYP1A1Induction

1996 • 54 citations

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Partial Characterization of the Human CYP1A1 Negatively Acting Transcription Factor and Mutational Analysis of Its Cognate DNA Recognition Sequence

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Interleukin-1β and Reactive Oxygen Species Mediate Activation of c-Jun NH2-Terminal Kinases, in Human Epithelial Cells, by Two Independent Pathways

1998 • 49 citations

Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines

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Physiological Role of the N-terminal Processed P4501A1 Targeted to Mitochondria in Erythromycin Metabolism and Reversal of Erythromycin-mediated Inhibition of Mitochondrial Protein Synthesis

1999 • 48 citations

Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor

1999 • 47 citations

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Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins

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Inhibition of the Transcription of CYP1A1 Gene by the Upstream Stimulatory Factor 1 in Rabbits

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Markedly Increased Constitutive CYP1A1 mRNA Levels in the Fertilized Ovum of the Mouse

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Biochemical Studies of a Patient with Hereditary Hepatorenal Tyrosinemia: Evidence of Glutathione Deficiency

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Tossing monkey wrenches into the clock: New ways of treating cancer

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Aryl Hydrocarbon Receptor Activation in Genital Tubercle, Palate, and Other Embryonic Tissues in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-ResponsivelacZMice

1998 • 41 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants

1993 • 40 citations

Constitutive and Inducible Cytochromes P450 in Rat Lung Mitochondria: Xenobiotic Induction, Relative Abundance, and Catalytic Properties

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Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion.

1989 • 38 citations

Oct-1 transcription factor is a negative regulator of rat CYP1A1 expression via an octamer sequence in its negative regulatory element.

1996 • 38 citations

Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity

1998 • 31 citations

Differential roles for Fos and Jun in DNA-binding: redoxdependent and independent functions

1993 • 27 citations

Nuclear transcription factor Oct-1 binds to the 5′-upstream region of CYP1A1 and negatively regulates its expression

1996 • 23 citations

Characterization of the rat Class 3 aldehyde dehydrogenase gene promoter

1996 • 23 citations

Persistent succinylacetone excretion after liver transplantation in a patient with hereditary tyrosinaemia type I

1984 • 23 citations

“Oxidative stress” response in liver of an untreated newborn mouse having a 1.2-centimorgan deletion on chromosome 7

1992 • 22 citations

MurineCyp1a-1Induction in Mouse Hepatoma Hepa-1C1C7 Cells by Myristicin

1997 • 22 citations

Genetically determined abnormalities of microsomal enzymes in liver of mutant newborn mice

1976 • 21 citations

Menadione Toxicity in Two Mouse Liver Established Cell Lines Having Striking Genetic Differences in Quinone Reductase Activity and Glutathione Concentrations

1993 • 20 citations

Suppression ofCYP1A1Transcription by H2O2Is Mediated by Xenobiotic-Response Element

1998 • 19 citations

Premature development of ligandin (GSH transferase B) in mice with an inherited defect in endoplasmic reticulum-golgi structure and function

1977 • 19 citations

Upstream Stimulatory Factor 1 (USF1) Suppresses Induction of CYP1A1 mRNA by 3-Methylcholanthrene (MC) in HepG2 Cells

1997 • 17 citations

Drug metabolism and signal transduction: Possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity

1994 • 16 citations

Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF‐7 and hepatoma HepG2 cells

1995 • 15 citations

Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines

2000 • 10 citations

Lipoxygenase Metabolites as Mediators of UTP-Induced Intracellular Acidification in Mouse RAW 264.7 Macrophages

1998 • 9 citations

Phospholipase A2 Activation and Increases in Specific Prostaglandins in the Oxidatively Stressed 14CoS/14CoS Mouse Hepatocyte Line

1998 • 9 citations

Cellular Responses To Oxidative Stress

1990 • 8 citations

Isolation and characterization of mouse hepatocyte lines carrying a lethal albino deletion.

1991 • 8 citations

Uncoupling of monooxygenation and electron transport by fluorocarbons in liver microsomes

1971 • 7 citations

Metabolic studies in a mouse model of hepatorenal tyrosinemia: Absence of perinatal abnormalities

1992 • 7 citations

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