Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

1998 • 1,081 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity

1996 • 820 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

1993 • 520 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.

1995 • 487 citations

Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB

1998 • 435 citations

A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1997 • 414 citations

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo

1997 • 410 citations

Species-Specific Recombinant Cell Lines as Bioassay Systems for the Detection of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-like Chemicals

1996 • 407 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1995 • 388 citations

Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

1998 • 375 citations

Negative Interaction between the RelA(p65) Subunit of NF-κB and the Progesterone Receptor

1996 • 353 citations

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

1988 • 268 citations

Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription

1996 • 245 citations

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture

1995 • 238 citations

Mutual Transcriptional Interference between RelA and Androgen Receptor

1996 • 217 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

CBP/p300 Functions as a Possible Transcriptional Coactivator of Ah Receptor Nuclear Translocator (Arnt)

1997 • 194 citations

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.

1992 • 177 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.

1993 • 160 citations

Cooperative Interaction between AhR·Arnt and Sp1 for the Drug-inducible Expression of CYP1A1 Gene

1996 • 160 citations

Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site

1998 • 160 citations

Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes.

1992 • 139 citations

Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor.

1991 • 136 citations

Thymic Alterations Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Are Strictly Dependent on Aryl Hydrocarbon Receptor Activation in Hemopoietic Cells

1998 • 129 citations

Characterization of the Mouse Cyp1B1 Gene

1998 • 128 citations

Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor.

1988 • 123 citations

Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.

1994 • 117 citations

Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice

1986 • 112 citations

Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice*1

1984 • 110 citations

alpha-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression.

1987 • 97 citations

Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells

1992 • 96 citations

Mechanism of Action of α-Naphthoflavone as an Ah Receptor Antagonist in MCF-7 Human Breast Cancer Cells

1993 • 92 citations

The mechanism of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1990 • 86 citations

Partial Characterization of the Human CYP1A1 Negatively Acting Transcription Factor and Mutational Analysis of Its Cognate DNA Recognition Sequence

1995 • 50 citations