Heat shock factors and the control of the stress response

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Heat Shock Transcription Factors: Structure and Regulation

1995 • 1,179 citations

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

1996 • 1,125 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Molecularchaperones as HSF1-specific transcriptional repressors

1998 • 623 citations

Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

1998 • 622 citations

Key features of heat shock regulatory elements.

1988 • 566 citations

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

1995 • 558 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Molecular cloning and expression of a human heat shock factor, HSF1.

1991 • 472 citations

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

1989 • 439 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.

1991 • 381 citations

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.

1992 • 376 citations

HSF4, a New Member of the Human Heat Shock Factor Family Which Lacks Properties of a Transcriptional Activator

1997 • 350 citations

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

1991 • 347 citations

Stress-Inducible Cellular Responses

1995 • 337 citations

Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation

1996 • 294 citations

Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation

1996 • 294 citations

Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury.

1994 • 285 citations

Activation of Heat Shock Factor 2 during Hemin-Induced Differentiation of Human Erythroleukemia Cells

1992 • 281 citations

Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects

1997 • 280 citations

18 Heat Shock Proteins and Stress Tolerance

1994 • 280 citations

Crystal Structure of the DNA Binding Domain of the Heat Shock Transcription Factor

1994 • 269 citations

Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.

1993 • 264 citations

Cooperative binding of drosophila heat shock factor to arrays of a conserved 5 bp unit

1991 • 250 citations

Negative regulation of the heat shock transcriptional response by HSBP1

1998 • 222 citations

Inhibition of nuclear factor κB by prostaglandin A₁: An effect associated with heat shock transcription factor activation

1997 • 194 citations

Antiproliferative prostaglandins activate heat shock transcription factor.

1992 • 183 citations

A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function

1995 • 180 citations

Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.

1995 • 179 citations

Heat shock proteins and stress tolerance.

1994 • 178 citations

Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.

1989 • 173 citations

The Transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions

1996 • 170 citations

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

1992 • 168 citations

Induction of Heat Stress Proteins Is Associated with Decreased Mortality in an Animal Model of Acute Lung Injury

1993 • 160 citations

Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress.

1993 • 157 citations

Trimerization of the heat shock transcription factor by a triple-stranded .alpha.-helical coiled-coil

1992 • 146 citations

Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved.

1990 • 145 citations

Stress proteins in inflammation

1996 • 132 citations

Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment.

1990 • 127 citations

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein.

1994 • 120 citations

Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance

1998 • 117 citations

Prostaglandin A Compounds as Antiviral Agents

1980 • 115 citations

Antiviral activity of cyclopentenone prostanoids

1997 • 109 citations

2-Cyclopenten-1-one, a New Inducer of Heat Shock Protein 70 with Antiviral Activity

1996 • 101 citations

Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression?

1996 • 98 citations

Sensing stress and responding to stress

1996 • 87 citations

Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors

1998 • 77 citations

Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.

1996 • 74 citations

Aspirin enhances thermotolerance in human erythroleukemic cells: an effect associated with the modulation of the heat shock response.

1995 • 60 citations

Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis

1994 • 59 citations

Stress Proteins in Inflammationa

1998 • 57 citations

2 Cytosolic hsp70s of Saccharomyces cerevisiae : Roles in Protein Synthesis, Protein Translocation, Proteolysis, and Regulation

1994 • 54 citations

Induction of ferritin and heat shock proteins by prostaglandin A₁ in human monocytes

1999 • 48 citations

Induction of Thermotolerance by Prostaglandin A in Human Cells

1993 • 43 citations

Inhibition of vesicular stomatitis virus replication by Δ12-prostaglandin J2 is regulated at two separate levels and is associated with induction of stress protein synthesis

1993 • 33 citations

Inhibition of HSP70 Expression by Calcium Ionophore A23187 in Human Cells

1996 • 31 citations

3 Chaperoning Mitochondrial Biogenesis

1994 • 29 citations

Induction of HSP70 by Prostaglandins

1990 • 23 citations

Cytosolic hsp70s of Saccharomyces cerevisiae: Roles in protein synthesis, protein translocation, proteolysis, and regulation

1994 • 21 citations

Induction of the heat‐shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1

1998 • 12 citations