Aromatic Hydrocarbon Receptor Interaction with the Retinoblastoma Protein Potentiates Repression of E2F-dependent Transcription and Cell Cycle Arrest

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

1977 • 1,556 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

1995 • 1,064 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells

1998 • 957 citations

Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity

1996 • 820 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 • 542 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

The AH-receptor: genetics, structure and function

1993 • 437 citations

Estrogen Receptor in a Human Cell Line (MCF-7) from Breast Carcinoma

1973 • 415 citations

A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1997 • 414 citations

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo

1997 • 410 citations

Control of pRB phosphorylation

1998 • 389 citations

Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

1995 • 369 citations

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 363 citations

INFECTION OF HUMAN AND SIMIAN TISSUE CULTURES WITH ROUS SARCOMA VIRUS

1964 • 354 citations

p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

1999 • 352 citations

Identification of Functional Domains of the Aryl Hydrocarbon Receptor

1995 • 322 citations

Differential Regulation of Retinoblastoma Protein Function by Specific Cdk Phosphorylation Sites

1996 • 306 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor

1999 • 296 citations

Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

1997 • 293 citations

Tumour promotion by TCDD in skin of HRS/J hairless mice

1982 • 293 citations

Cancer mortality among workers in chemical plant contaminated with dioxin

1991 • 286 citations

The Aromatic Hydrocarbon Receptor Modulates the Hepa 1c1c7 Cell Cycle and Differentiated State Independently of Dioxin

1996 • 273 citations

Functional Interactions between the hBRM/hBRG1 Transcriptional Activators and the pRB Family of Proteins

1996 • 252 citations

A Direct Interaction between the Aryl Hydrocarbon Receptor and Retinoblastoma Protein

1998 • 249 citations

Constitutive Activation of the Aromatic Hydrocarbon Receptor

1998 • 241 citations

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

1993 • 239 citations

pRB plays an essential role in cell cycle arrest induced by DNA damage

1998 • 238 citations

The Petinoblastoma Tumor Suppressor Protein

1994 • 215 citations

Inhibition of DNA synthesis by RB: effects on G₁/S transition and S-phase progression

1998 • 209 citations

Exposure to Polychlorinated Dioxins and Furans (PCDD/F) and Mortality in a Cohort of Workers from a Herbicide-producing Plant in Hamburg, Federal Republic of Germany

1995 • 202 citations

Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albumin

1973 • 171 citations

Complementation of Ah Receptor Deficiency in Hepatoma Cells: Negative Feedback Regulation and Cell Cycle Control by the Ah Receptor

1996 • 167 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Correlation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induction of Cytochrome P4501A in Vascular Endothelium with Toxicity in Early Life Stages of Lake Trout

1997 • 163 citations

Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Interaction of the Ah and hr loci

1982 • 156 citations

Immunological effects of chlorinated dibenzo-p-dioxins.

1995 • 151 citations

Reproductive Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Male Rats: Different Effects of in Utero Versus Lactational Exposure

1994 • 149 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

Evidence for the Induction of Apoptosis in Thymocytes by 2,3,7,8-Tetrachlorodibenzo-p-dioxinin Vivo

1997 • 137 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters cardiovascular and craniofacial development and function in sac fry of rainbow trout (Oncorhynchus mykiss)

1999 • 131 citations

Chloracne, "the hallmark of dioxin intoxication".

1985 • 123 citations

Promotion of Endometriosis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Rats and Mice: Time–Dose Dependence and Species Comparison

1996 • 123 citations

Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression

1990 • 117 citations

Dioxin induces transforming growth factor-alpha in human keratinocytes

1991 • 114 citations

Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.

1996 • 109 citations

Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor beta 1.

1996 • 100 citations

Partial Demasculinization and Feminization of Sex Behavior in Male Rats by in Utero and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Not Associated with Alterations in Estrogen Receptor Binding or Volumes of Sexually Differentiated Brain

1994 • 99 citations

Retinoblastoma protein in growth suppression and death protection

1997 • 91 citations

Environmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans.

1993 • 83 citations

Aryl Hydrocarbon Receptor-Mediated Antiestrogenicity in MCF-7 Cells: Modulation of Hormone-Induced Cell Cycle Enzymes

1998 • 81 citations

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

1996 • 81 citations

Review of the interaction between TCDD and glucocorticoids in embryonic palate

1995 • 76 citations

Growth Suppression by an E2F-Binding-Defective Retinoblastoma Protein (RB): Contribution from the RB C Pocket

1998 • 73 citations

Quantitative Analysis of Enzyme-Altered Liver Foci in Rats Initiated with Diethylnitrosamine and Promoted with 2,3,7,8-Tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin

1996 • 67 citations

Long-term effects of chemical disasters. Lessons and results from Seveso

1991 • 63 citations

Aryl Hydrocarbon Receptor Regulation of Ceramide-induced Apoptosis in Murine Hepatoma 1c1c7 Cells

1999 • 56 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Hyperplasia in Confluent Cultures of Human Keratinocytes

1984 • 56 citations

Dioxins: model chemicals for assessing receptor-mediated toxicity

1995 • 53 citations

Regulation of Gene Expression and Acceleration of Differentiation in Human Keratinocytes by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1994 • 49 citations

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes invivo

1989 • 34 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro: H4IIEC3-derived 5L hepatoma cells as a model system

1991 • 33 citations

Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.

1998 • 31 citations

Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin a deficiency

1991 • 31 citations

Phenotypic Analysis of Spleen, Thymus, and Peripheral Blood Cells in Aged C57B1/6 Mice Following Long-Term Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

1995 • 28 citations

Growth stimulation of primary rat hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1993 • 25 citations

Polycyclic aromatic hydrocarbons enhance terminal cell death of human ectocervical cells.

1998 • 25 citations

Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130

1998 • 20 citations

Modulation of Protein Kinase C-Related Signal Transduction by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exhibits Cell Cycle Dependence

1996 • 15 citations

Induction of Highly Proliferative Phenotypes in Cultured Glomerular Mesangial Cells by Benzo[a]pyrene Alone or in Combination with Methoxamine

1995 • 13 citations

Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines

1987 • 13 citations