Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF‐7 and hepatoma HepG2 cells

Current protocols in molecular biology

1988 • 4,543 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Polycyclic Hydrocarbons and Cancer

1981 • 737 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

The AH-receptor: genetics, structure and function

1993 • 437 citations

Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transductiona

1993 • 425 citations

The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds☆

1994 • 380 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Progress in drug metabolism

1977 • 309 citations

Functional significance of different human CYPlAl genotypes

1994 • 308 citations

The Cytochrome P450 I Gene Family of Microsomal Hemoproteins and Their Role in the Metabolic Activation of Chemicals

1990 • 222 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

BK Viral Enhancer Element and a Human Cellular Homolog

1983 • 175 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

Identification of multiple regulatory elements on the human cytochrome P450IA1 gene

1988 • 122 citations

Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin

1991 • 110 citations

Interindividual difference in expression of human Ah receptor and related P450 genes

1994 • 97 citations

A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.

1990 • 96 citations

Classification of members of the Ah gene battery

1992 • 95 citations

Superinduction of CYP1A1 transcription by cycloheximide. Role of the DNA binding site for the liganded Ah receptor.

1992 • 89 citations

Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450

1984 • 78 citations

Nonresponsiveness of normal human fibroblasts to dioxin correlates with the presence of a constitutive xenobiotic response element-binding factor.

1993 • 71 citations

Involvement of Dihydrodiols and Diol Epoxides in the Metabolic Activation of Polycyclic Hydrocarbons Other than Benzo[a]pyrene

1981 • 70 citations

Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene

1993 • 62 citations

Mechanism of dioxin action: receptor-enhancer interactions in intact cells

1993 • 59 citations

Mechanism of Action of a Repressor of Dioxin-Dependent Induction of Cyplal Gene Transcription

1992 • 54 citations

Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta.

1984 • 49 citations

Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.

1994 • 47 citations

Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.

1994 • 47 citations

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.

1992 • 36 citations

Expression of cytochrome P450IA in breast cancer

1991 • 35 citations

Progress in drug metabolism

1981 • 29 citations

Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?

1991 • 29 citations

Potentiation of CYP1A1 Gene Expression in MCF-7 Human Breast Cancer Cells Cotreated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and 12-O-Tetradecanoylphorbol-13-Acetate

1993 • 28 citations

Induction of cytochrome P-450IA1 gene expression in human breast tumour cell lines

1988 • 23 citations

Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors

1991 • 21 citations

Cell specific activation of benzo[a]pyrene by fibroblasts and hepatocytes

1983 • 19 citations

Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines

1993 • 16 citations

In vitro binding and functional studies comparing the human CYPIAI negative regulatory element with the orthologous sequences from rodent genes

1995 • 14 citations

Alterations in the Ah Receptor Level after Staurosporine Treatment

1993 • 12 citations