Aryl Hydrocarbon Receptor-Mediated Signal Transduction

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Organohalogen compounds

1995 • 1,125 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

1995 • 1,064 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action

1984 • 793 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain

1993 • 723 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

1994 • 503 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

1991 • 499 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states

1969 • 425 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

Structure and function of the b/HLH/Z domain of USF.

1994 • 390 citations

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1995 • 388 citations

The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds☆

1994 • 380 citations

Mechanistic aspects of dioxin action

1993 • 372 citations

Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

1995 • 369 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.

1987 • 340 citations

STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS*

1979 • 336 citations

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 • 336 citations

Cloning and expression of a human Ah receptor cDNA.

1993 • 334 citations

The Ah receptor and the mechanism of dioxin toxicity

1991 • 330 citations

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

1994 • 327 citations

Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements

1987 • 323 citations

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.

1990 • 316 citations

Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization

1991 • 312 citations

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

1994 • 308 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene.

1974 • 293 citations

Helix-loop-helix proteins as regulators of muscle-specific transcription.

1993 • 293 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

1991 • 289 citations

Analysis of the four alleles of the murine aryl hydrocarbon receptor.

1994 • 288 citations

Characterization of a prototype strain of hepatitis E virus.

1992 • 288 citations

The Regulation of Cytochrome P-450 Gene Expression

1986 • 283 citations

Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site.

1991 • 275 citations

Control of Cytochrome P ₁ -450 Gene Expression by Dioxin

1985 • 272 citations

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

1989 • 260 citations

The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 251 citations

TBP-TAF complexes: selectivity factors for eukaryotic transcription

1994 • 250 citations

Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).

1994 • 249 citations

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

1994 • 247 citations

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

1992 • 242 citations

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

1993 • 239 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

1975 • 238 citations

Characterization of the gene for a protein kinase which phosphorylates the sporulation-regulatory proteins Spo0A and Spo0F of Bacillus subtilis

1989 • 235 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

1992 • 230 citations

Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines.

1980 • 227 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship.

1973 • 218 citations

Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor Complex

1989 • 215 citations

Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse

1972 • 213 citations

Overview on environmental fate of chlorinated dioxins and dibenzofurans. Sources, levels and isomeric pattern in various matrices

1987 • 211 citations

Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.

1994 • 209 citations

Molecular Mechanism of Inhibition of Estrogen-Induced Cathepsin D Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in MCF-7 Cells

1995 • 205 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

Single amino acid substitutions alter helix-loop-helix protein specificity for bases flanking the core CANNTG motif.

1992 • 199 citations

The cytosolic receptor binding affinities and ahh induction potencies of 29 polynuclear aromatic hydrocarbons

1986 • 194 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.

1995 • 190 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA

1982 • 184 citations

The genetics of aryl hydrocarbon hydroxylase induction in mice: A single gene difference between C57BL/6J and DBA/2J

1972 • 184 citations

Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

1992 • 179 citations

The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.

1994 • 178 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Tissue specific expression of the rat Ah-receptor and ARNT mRNAs

1994 • 175 citations

Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P₁450 gene

1985 • 174 citations

Nuclear uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Role of the hepatic cytosol receptor protein.

1979 • 173 citations

Sources and fate of PCDDs and PCDFs: An overview

1985 • 172 citations

Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.

1992 • 171 citations

Identification of a Rat Adrenal Cytochrome P450 Active in Polycyclic Hydrocarbon Metabolism as Rat CYP1B1

1995 • 169 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

Regulation of cytochrome P1-450 gene transcription by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells.

1984 • 166 citations

Molecular Characterization of Helix-Loop-Helix Peptides

1992 • 166 citations

Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex.

1994 • 165 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene.

1989 • 161 citations

Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

1993 • 161 citations

Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation.

1994 • 160 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.

1993 • 160 citations

Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini.

1994 • 160 citations

Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis

1993 • 159 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

Mechanism of action and structure-activity relationships for the chlorinated dibenzo-p-dioxins and related compounds

1989 • 154 citations

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1994 • 152 citations

The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system.

1994 • 151 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Dioxins and Dioxin-like Compounds: Model Validation and Ah Receptor Characterization

1995 • 149 citations

Transcription factors 2: helix-loop-helix.

1995 • 149 citations

Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system.

1986 • 146 citations

Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.

1985 • 145 citations

Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene.

1986 • 140 citations

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

1992 • 139 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.

1984 • 134 citations

A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.

1994 • 134 citations

DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer

1992 • 133 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

1992 • 126 citations

Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

1994 • 125 citations

Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression.

1994 • 124 citations

Keratinization of mouse teratoma cell line XB produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: An in vitro model of toxicity

1980 • 124 citations

Identification of multiple regulatory elements on the human cytochrome P450IA1 gene

1988 • 122 citations

Reconstitution of transcription with five purified initiation factors and RNA polymerase II from Saccharomyces cerevisiae

1992 • 121 citations

Myogenesis and developmental control genes

1990 • 121 citations

Heat shock protein hsp90 regulates dioxin receptor function in vivo.

1995 • 120 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors in wild type and variant mouse hepatoma cells. Nuclear location and strength of nuclear binding.

1984 • 120 citations

Distinct Roles of the Molecular Chaperone hsp90 in Modulating Dioxin Receptor Function via the Basic Helix-Loop-Helix and PAS Domains

1995 • 118 citations

Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.

1990 • 117 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric

1990 • 115 citations

Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells.

1983 • 114 citations

Dioxin induces transforming growth factor-alpha in human keratinocytes

1991 • 114 citations

Polychlorinated Dibenzo-p-dioxins and Polychlorinated Dibenzofurans: The Risks to Human Health. A Review

1989 • 111 citations

Physicochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocator: characterization of two monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator.

1994 • 110 citations

Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

1977 • 109 citations

Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.

1996 • 109 citations

Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats

1987 • 108 citations

Regulation of CYP1A1 by Indolo[3,2-b]carbazole in Murine Hepatoma Cells

1995 • 106 citations

Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment.

1991 • 104 citations

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

1994 • 101 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.

1993 • 100 citations

Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.

1993 • 100 citations

Organization and function of a dioxin-responsive enhancer.

1990 • 99 citations

Constitutive Function of the Basic Helix-Loop-Helix/PAS Factor Arnt.

1995 • 99 citations

Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals

1995 • 98 citations

Orientation of the heterodimeric aryl hydrocarbon (dioxin) receptor complex on its asymmetric DNA recognition sequence.

1995 • 97 citations

Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1992 • 96 citations

Regulatory gene product of the Ah complex. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene binding to several moieties in mouse liver cytosol.

1981 • 92 citations

The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.

1989 • 90 citations

The Potential Role of DNA Methylation in the Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1989 • 89 citations

Dioxin Induces Localized, Graded Changes in Chromatin Structure: Implications forCyp1A1Gene Transcription

1995 • 89 citations

Characterization of multiple forms of the Ah receptor: comparison of species and tissues

1989 • 85 citations

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

1992 • 85 citations

Environmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans.

1993 • 83 citations

Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.

1992 • 83 citations

Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting.

1992 • 82 citations

Transcriptional Activation by the Mouse Ah Receptor.

1995 • 80 citations

The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. A comparison with the glucocorticoid receptor and the mouse and rat hepatic dioxin receptors.

1987 • 79 citations

Circadian Clock Genes Are Ticking

1992 • 79 citations

Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.

1988 • 78 citations

Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats

1996 • 74 citations

Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten.

1991 • 74 citations

Physicochemical characterization of specific and nonspecific polyaromatic hydrocarbon binders in rat and mouse liver cytosol.

1983 • 73 citations

Histones, nucleosomes and transcription

1993 • 72 citations

Nonresponsiveness of normal human fibroblasts to dioxin correlates with the presence of a constitutive xenobiotic response element-binding factor.

1993 • 71 citations

Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 71 citations

Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.

1992 • 69 citations

Polyanionic-binding properties of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. A comparison with the glucocorticoid receptor.

1986 • 63 citations

Direct interaction of the tau 1 transactivation domain of the human glucocorticoid receptor with the basal transcriptional machinery.

1993 • 63 citations

Ah Receptor Phosphorylation: Localization of Phosphorylation Sites to the C-Terminal Half of the Protein

1995 • 62 citations

Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer

1991 • 61 citations

Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element.

1993 • 60 citations

Mechanism of dioxin action: receptor-enhancer interactions in intact cells

1993 • 59 citations

Functional analysis of the transcriptional promoter for the CYP1A1 gene.

1990 • 58 citations

Transcriptional activation domains of the Ah receptor and Ah receptor nuclear translocator

1995 • 57 citations

Regulatory elements involved in constitutive and phorbol ester-inducible expression of the plasminogen activator inhibitor type 2 gene promoter

1991 • 55 citations

Mechanism of Action of a Repressor of Dioxin-Dependent Induction of Cyplal Gene Transcription

1992 • 54 citations

Inhibition of the 17β-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus

1991 • 54 citations

Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone

1984 • 54 citations

Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria

1989 • 52 citations

Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

1991 • 51 citations

Partial Characterization of the Human CYP1A1 Negatively Acting Transcription Factor and Mutational Analysis of Its Cognate DNA Recognition Sequence

1995 • 50 citations

Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes.

1990 • 50 citations

Interactions of rutaecarpine alkaloids with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver

1989 • 49 citations

Predicted Structural Similarities of the DNA Binding Domains of c-Myc and Endonuclease Eco RI

1992 • 49 citations

Baculovirus expression of the Ah receptor and Ah receptor nuclear translocater. Evidence for additional dioxin responsive element-binding species and factors required for signaling

1994 • 46 citations

Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: Evidence for two distinct heteromeric DNA-binding forms

1993 • 45 citations

Ah receptor for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

1986 • 43 citations

The DNA Binding of Purified Ah Receptor Heterodimer Is Regulated by Redox Conditions

1995 • 43 citations

Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes.

1995 • 42 citations

Human Arylhydrocarbon Receptor: Functional Expression and Chromosomal Assignment to 7p211

1994 • 39 citations

Synthesis and characterization of twenty-two purified polychlorinated dibenzofuran congeners

1984 • 39 citations

In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene.

1987 • 38 citations

The aryl hydrocarbon (Ah) receptor

1988 • 38 citations

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.

1992 • 36 citations

Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice.

1995 • 36 citations

Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor.

1994 • 34 citations

Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT)

1994 • 33 citations

Rat CYP1A1 negative regulatory element: biological activity and interaction with a protein from liver and hepatoma cells.

1993 • 33 citations

The hepatic Ah receptor for 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Species differences in subunit dissociation

1990 • 33 citations

Polychlorinated Dibenzo-p-dioxins and -furans (PCDDs/PCDFs): Sources and Environmental Impact, Epidemiology, Mechanisms of Action, Health Risks

1990 • 32 citations

Intracellular location of the Ah receptor

1986 • 32 citations

Dioxin-inducible, Ah receptor-dependent transcription in vitro.

1990 • 30 citations

Protein Kinase C Is Not Involved in Ah Receptor Transformation and DNA Binding

1993 • 30 citations

Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence—a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription

1994 • 30 citations

The glucocorticoid receptor functions at multiple steps during transcription initiation by RNA polymerase II.

1994 • 30 citations

In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines

1992 • 29 citations

Rat liver DT-diaphorase: Regulation of functional mRNA levels by 3-methylcholanthrene, trans-stilbene oxide, and phenobarbital

1984 • 29 citations

Structure of the 5′ Flanking Region of Class 3 Aldehyde Dehydrogenase in the Rat

1994 • 28 citations

Guidelines for nomenclature of genetically determined biochemical variants in the house mouse, Mus musculus

1973 • 27 citations

PCDDs and PCDFs: Sources and Environmental Impact

1990 • 24 citations

Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of aldehyde dehydrogenase in hepatoma cells

1992 • 21 citations

Evidence for two functionally distinct forms of the human Ah receptor

1995 • 16 citations

Purification to homogeneity of the heteromeric DNA-binding form of the aryl hydrocarbon receptor from rat liver.

1994 • 15 citations

Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.

1993 • 13 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces the nuclear translocation of two XRE binding proteins in mice

1993 • 12 citations

Nuclear Ah receptor from mouse hepatoma cells: Effect of partial proteolysis on relative molecular mass and DNA-binding properties

1990 • 10 citations

Molecular Mechanisms of Steroid Hormone Action.

1973 • 3 citations