Taxol selectively blocks microtubule dependent NF-κB activation by phorbol ester via inhibition of IκBα phosphorylation and degradation

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1971 • 3,891 citations

NF-κB: Ten Years After

1996 • 3,008 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

1992 • 376 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

1995 • 354 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

Role of Diacylglycerol-Regulated Protein Kinase C Isotypes in Growth Factor Activation of the Raf-1 Protein Kinase

1997 • 292 citations

Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.

1995 • 276 citations

Activation of NF-κB by Antineoplastic Agents

1997 • 271 citations

Helenalin, an Anti-Inflammatory Sesquiterpene Lactone from Arnica, Selectively Inhibits Transcription Factor NF-κB

1997 • 248 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways

1997 • 239 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

How does taxol stabilize microtubules?

1995 • 233 citations

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

1997 • 225 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation

1997 • 194 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

IκBα Physically Interacts with a Cytoskeleton-Associated Protein through Its Signal Response Domain

1997 • 144 citations

Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis

1996 • 130 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

Lambda-Interacting Protein, A Novel Protein That Specifically Interacts with the Zinc Finger Domain of the Atypical Protein Kinase C Isotype λ/ι and Stimulates Its Kinase Activity In Vitro and In Vivo

1996 • 121 citations

Divergent Functional Roles for p90 Kinase Domains

1995 • 103 citations

Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II).

1990 • 91 citations

Identification of Tumor-Specific Paclitaxel (Taxol)-Responsive Regulatory Elements in the Interleukin-8 Promoter

1997 • 90 citations

Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors

1994 • 86 citations

Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.

1997 • 83 citations

Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages.

1995 • 83 citations

Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells.

1996 • 83 citations

Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes

1996 • 82 citations

Pericolic mesenteric lymph nodes: an aid in distinguishing diverticulitis from cancer of the colon.

1997 • 75 citations

Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation

1993 • 59 citations

Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells

1993 • 50 citations

Control of signal transduction and morphogenesis by Ras

1995 • 48 citations

Differential Effect of Activators of Protein Kinase C on Cytoskeletal Changes in Mouse and Hamster Eggs

1995 • 39 citations

Cytoskeletal architecture in mouse lung epithelial cells is regulated by protein-kinase C-alpha and calpain II

1996 • 39 citations

Protein kinase C isoform expression during the differentiation of 3T3-L1 preadipocytes: Loss of protein kinase C-α isoform correlates with loss of phorbol 12-myristate 13-acetate activation of nuclear factor κB and acquisition of the adipocyte phenotype

1996 • 33 citations

Phorbol esters and PKC signaling regulate proliferation, vimentin cytoskeleton assembly and glutamine synthetase activity of chick embryo cerebrum astrocytes in culture

1995 • 30 citations

Focal adhesion formation is associated with secretion of allergic mediators

1995 • 24 citations

Isolation and cloning of a Drosophila homolog to the mammalian RACK1 gene, implicated in PKC-mediated signalling

1997 • 24 citations

Activation of mitogen‐activated protein kinase by protein kinase C isotypes α, β_I and γ, but not ϵ

1996 • 22 citations

Binding of CD44 to Hyaluronic Acid Can Be Induced by Multiple Signals and Requires the CD44 Cytoplasmic Domain

1996 • 22 citations

Biological specificity and measurable physical properties of cell surface receptors and their possible role in signal transduction through the cytoskeleton

1995 • 20 citations

Colchicine affects protein kinase C‐induced modulation of synaptic transmission in cultured hippocampal pyramidal cells

1997 • 15 citations

Two‐step mechanism for actin polymerization in human erythroleukemia cells induced by phorbol ester

1994 • 14 citations

Motility of intracellular particles in rat fibroblasts is greatly enhanced by phorbol ester and by over-expression of normal p21N-ras

1993 • 14 citations

Microfilament Assembly Is Required for Anti-IgM Dependent Mapk and p90rsk Activation in Human B Lymphocytes

1995 • 12 citations

Polymorphonuclear leukocyte opsonic receptor expression after hypoxia/reoxygenation

1996 • 11 citations

Retrovirus-mediated transfer of nuclear factor-kappa B subunit genes modulates I kappa B alpha and interferon beta expression.

1995 • 8 citations

What's Hiding in Hidden?

1996 • 2 citations