The cytopathic effect of hiv is associated with apoptosis

Methods in Enzymology , Vol

1966 • 26,261 citations

Abnormalities of B-Cell Activation and Immunoregulation in Patients with the Acquired Immunodeficiency Syndrome

1983 • 1,625 citations

Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.

1979 • 1,532 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization.

1986 • 740 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus

1985 • 706 citations

Action of micrococcal nuclease on chromatin and the location of histone H1

1977 • 686 citations

Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome

1984 • 639 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Death and the cell

1986 • 616 citations

HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists

1990 • 595 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Alterations in T4 (CD4) Protein and mRNA Synthesis in Cells Infected with HIV

1986 • 360 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.

1988 • 299 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS

1988 • 223 citations

LAV Revisited: Origins of the Early HIV-1 Isolates from Institut Pasteur

1991 • 210 citations

An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells

1987 • 191 citations

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

1988 • 160 citations

Rabbit Antibodies to Histone Fractions As Specific Reagents for Preparative and Comparative Studies

1970 • 160 citations

Core Particle, Fiber, and Transcriptionally Active Chromatin Structure

1986 • 159 citations

IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death.

1989 • 158 citations

Enhancement of HIV-1 Cytocidal Effects in CD4 ⁺ Lymphocytes by the Aids-associated Mycoplasma

1991 • 152 citations

AIDS virus infection and autoimmunity: A perspective of the clinical, immunological, and molecular origins of the autoallergic pathologies associated with HIV disease

1991 • 112 citations

Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes.

1990 • 112 citations

[1] Preparation of nucleosomes and chromatin

1989 • 104 citations

Molecular biology of HIV

1989 • 75 citations

CD4+ lymphocyte function with early human immunodeficiency virus infection.

1989 • 73 citations

Loss of CD4 membrane expression and CD4 mRNA during acute human immunodeficiency virus replication.

1988 • 70 citations

Defective signal transduction—a common pathway for cellular dysfunction in HIV infection?

1990 • 69 citations

Characterization of human immunodeficiency virus type 2 envelope glycoproteins: dimerization of the glycoprotein precursor during processing

1989 • 64 citations

IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors.

1989 • 55 citations

Use of histone antibodies for studying chromatin topography and the phosphorylation of chromatin subunits.

1984 • 50 citations

Immunochemical detection of changes in chromatin subunits induced by histone H4 acetylation.

1982 • 49 citations

Characterization of an HIV-2-related virus with a smaller sized extracellular envelope glycoprotein

1989 • 46 citations

Death and transfiguration of cortical thymocytes: a reconsideration

1990 • 42 citations

Unintegrated human immunodeficiency virus type 1 DNA in chronically infected cell lines is not correlated with surface CD4 expression

1991 • 41 citations

Cell surface expression of several species of human immunodeficiency virus type 1 major core protein

1989 • 38 citations

Immunogenicity of free histones and of histones complexed with RNA

1991 • 25 citations

How do human immunodeficiency viruses enter cells?

1987 • 23 citations

Deleted Work

1955 • 0 citations