Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

1993 • 1,049 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

Regulation of apoptosis by viral gene products

1997 • 639 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

1997 • 600 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Translational Regulation of Yeast GCN4

1997 • 533 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Interactions between double-stranded RNA regulators and the protein kinase DAI.

1992 • 475 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

The Phosphorylation State of Eucaryotic Initiation Factor 2 Alters Translational Efficiency of Specific mRNAs

1989 • 393 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase

1998 • 380 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

1997 • 353 citations

Interferon-Induced Antiviral Actions and Their Regulation

1993 • 338 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

The Interferon-induced Double-Stranded RNA-Activated Protein Kinase Induces Apoptosis

1994 • 322 citations

Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli Through Blockage of Mitochondrial Release of Cytochrome C and Activation of Caspase-3

1998 • 319 citations

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1995 • 288 citations

Release of cytochrome c and decrease of cytochrome c oxidase in Bax‐expressing yeast cells, and prevention of these effects by coexpression of Bcl‐x_L

1997 • 288 citations

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

1993 • 265 citations

A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System

1997 • 262 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 207 citations

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

1978 • 206 citations

Polymorphism of murine Fas ligand that affects the biological activity

1997 • 201 citations

Tumor-suppressor genes: news about the interferon connection.

1993 • 199 citations

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

1995 • 194 citations

Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells

1997 • 192 citations

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

1993 • 183 citations

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

1983 • 177 citations

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1997 • 174 citations

Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis

1997 • 174 citations

mRNA translation: influence of the 5′ and 3′ untranslated regions

1994 • 173 citations

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.

1996 • 171 citations

Structure of the human APO‐1 gene

1994 • 165 citations

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.

1989 • 163 citations

The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins

1994 • 162 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI

1992 • 151 citations

HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

1995 • 149 citations

The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR

1997 • 146 citations

Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection

1996 • 144 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.

1994 • 136 citations

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

1993 • 132 citations

The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1

1997 • 124 citations

Effect of Brain Ischemia and Reperfusion on the Localization of Phosphorylated Eukaryotic Initiation Factor 2α

1997 • 120 citations

Translational efficiency of polycistronic mRNAs and their utilization to express heterologous genes in mammalian cells.

1987 • 118 citations

Structural Requirements for Double-Stranded RNA Binding, Dimerization, and Activation of the Human eIF-2α Kinase DAI in Saccharomyces cerevisiae

1995 • 116 citations

Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR

1994 • 96 citations

STAT1 Is Inactivated by a Caspase

1998 • 94 citations

Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells.

1992 • 93 citations

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase.

1993 • 90 citations

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.

1994 • 83 citations

The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Inhibits the Replication of Vaccinia Virus

1993 • 82 citations

Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR

1995 • 81 citations

Molecular Mechanisms Responsible for Malignant Transformation by Regulatory and Catalytic Domain Variants of the Interferon-induced Enzyme RNA-dependent Protein Kinase

1995 • 79 citations

TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine

1991 • 67 citations

Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors

1993 • 66 citations

Growth Control of Translation in Mammalian Cells

1995 • 64 citations

Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region

1992 • 63 citations

Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs

1994 • 61 citations

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

1991 • 59 citations

Detection of protein kinase homologues and viral RNA-binding domains utilizing polyclonal antiserum prepared against a baculovirus-expressed ds RNA-activated 68,000-Da protein kinase

1992 • 53 citations

Games viruses play: a strategic initiative against the interferon-induced dsRNA activated 68,000 Mr protein kinase

1993 • 50 citations

Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2.

1992 • 50 citations

Translational effects and sequence comparisons of the three serotypes of the reovirus S4 gene

1992 • 40 citations

Troglitazone Increases System A Amino Acid Transport in 3T3-L1 Cells

1998 • 14 citations

Deleted Work

1955 • 0 citations