Type I interferons are essential mediators of apoptotic death in virally infected cells

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

The Fas Death Factor

1995 • 4,070 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

p53 function and dysfunction

1992 • 1,918 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

The Treatment of Chronic Viral Hepatitis

1997 • 974 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Host factors and the pathogenesis of HIV-induced disease

1996 • 857 citations

Regulators of cell death

1995 • 647 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

1993 • 495 citations

Apoptosis: a mechanism of cell killing by influenza A and B viruses

1994 • 431 citations

Interferons and other regulatory cytokines

1988 • 429 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Interferons and Other Cytokines

1997 • 364 citations

Interferon-Induced Antiviral Actions and Their Regulation

1993 • 338 citations

Viruses and apoptosis

1995 • 324 citations

Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons

1994 • 306 citations

Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies

1996 • 235 citations

Apoptosis in Viral Infections

1995 • 210 citations

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

1994 • 186 citations

ISGF3γ p48, a specificity switch for interferon activated transcription factors

1996 • 131 citations

IRF-1: the transcription factor linking the interferon response and oncogenesis

1997 • 121 citations

Induction of apoptotic cell death in non‐melanoma skin cancer by interferon‐α

1995 • 107 citations

Increased Susceptibility of Cells Treated with Interferon to the Toxicity of Polyriboinosinic·Polyribocytidylic Acid

1972 • 98 citations

Virus-Induced Apoptosis

1997 • 73 citations

Antiviral immunity

1997 • 69 citations

Therapy of acute and chronic viral hepatitis.

1994 • 68 citations

Mechanism of Interferon Beta-Induced Squamous Differentiation and Programmed Cell Death in Human Non--Small--Cell Lung Cancer Cell Lines

1995 • 61 citations

Double-Stranded RNA and Interferon Action

1987 • 47 citations

Specificity of Interferon-induced Enhancement of Toxicity for Double-stranded Ribonucleic Acids

1973 • 41 citations