The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Structure of an IκBα/NF-κB Complex

1998 • 792 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

1998 • 759 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China

1998 • 619 citations

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

1998 • 578 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

Hundreds of ankyrin‐like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally?

1993 • 504 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

1998 • 287 citations

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.

1992 • 234 citations

A novel DNA recognition mode by the NF-κB p65 homodimer

1998 • 229 citations

The ANK repeat: a ubiquitous motif involved in macromolecular recognition

1992 • 225 citations

Casein Kinase II Phosphorylates IκBα at S-283, S-289, S-293, and T-291 and Is Required for Its Degradation

1996 • 187 citations

Distinct Functional Properties of IκBα and IκBβ

1997 • 166 citations

Constitutive Phosphorylation of IκBα by Casein Kinase II Occurs Preferentially at Serine 293: Requirement for Degradation of Free IκBα

1996 • 164 citations

An IkappaB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages

1996 • 159 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

IκBα Functions through Direct Contacts with the Nuclear Localization Signals and the DNA Binding Sequences of NF-κB

1998 • 151 citations

Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

1992 • 140 citations

TOM: a FRODO subpackage for protein-ligand fitting with interactive energy minimization

1987 • 136 citations

Inhibition of Nuclear Factor κB Activation by a Virus-encoded IκB-like Protein

1998 • 136 citations

Structure of the human NF-kappa B p52 homodimer-DNA complex at 2.1Aresolution

1997 • 134 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers

1995 • 122 citations

Structure of the cyclin-dependent kinase inhibitor p19Ink4d

1997 • 96 citations

Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

1998 • 87 citations

The role of DNA in the mechanism of NFκB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits

1997 • 80 citations

The N-Terminal Domain of IκBα Masks the Nuclear Localization Signal(s) of p50 and c-Rel Homodimers

1998 • 63 citations

Interactions of a Rel protein with its inhibitor.

1995 • 48 citations

Regulated Nuclear Import of the Drosophila Rel Protein Dorsal: Structure-Function Analysis

1996 • 35 citations

Deleted Work

1955 • 0 citations