Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Current protocols in molecular biology

1988 • 7,584 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Apoptosis by Death Factor

1997 • 5,038 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1997 • 749 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

1993 • 480 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

DNA-Protein Interactions

1972 • 412 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators

1994 • 374 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

1996 • 340 citations

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1995 • 293 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

A constitutive promoter directs expression of the nerve growth factor receptor gene.

1988 • 280 citations

Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness.

1994 • 262 citations

Transcription from TATA-less promoters: dihydrofolate reductase as a model.

1993 • 241 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

1993 • 210 citations

A Novel Gene Product that Couples TCR Signaling to Fas(CD95) Expression in Activation-Induced Cell Death

1996 • 196 citations

Fas/Fas Ligand Interaction Contributes to UV-Induced Apoptosis in Human Keratinocytes

1997 • 183 citations

Structure of the human APO‐1 gene

1994 • 165 citations

Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site

1998 • 160 citations

A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers.

1994 • 155 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Human Tumor Necrosis Factor Receptor p75/80 (CD120b) Gene Structure and Promoter Characterization

1996 • 144 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Sp1 Is a Component of the Cytokine-inducible Enhancer in the Promoter of Vascular Cell Adhesion Molecule-1

1995 • 121 citations

Inducible Expression of IκBα Repressor Mutants Interferes with NF-κB Activity and HIV-1 Replication in Jurkat T Cells

1998 • 85 citations

Cyclosporin A interferes with the inducible degradation of NF-xB inhibitors, but not with the processing of p105/NF-xB1 in T cells

1997 • 79 citations

A Constitutive Promoter Directs Expression of the Nerve Growth Factor Receptor Gene

1988 • 72 citations

Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression

1995 • 71 citations

Differential expression of APO‐1 on human thymocytes: Implications for negative selection?

1994 • 67 citations

Structural and functional analyses of DNA bending induced by Sp1 family transcription factors 1 1Edited by T. Richmond

1997 • 55 citations

Binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1-infected quiescent peripheral blood mononuclear cells reveals latent infection.

1996 • 49 citations

Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells.

1997 • 49 citations

Cloning and partial characterization of the promoter for the human p55 tumor necrosis factor (TNF) receptor

1993 • 48 citations

Genomic organization and promoter function of the murine tumor necrosis factor receptor β gene

1993 • 37 citations

Transcription factors: essential data.

1996 • 15 citations

Deleted Work

1955 • 0 citations