Recent advances in tumor necrosis factor and CD40 signaling

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Two TNF receptors

1992 • 1,048 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Death and the cell

1986 • 616 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

1994 • 488 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

ICE-like proteases in apoptosis

1995 • 353 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

1993 • 341 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis

1995 • 205 citations

Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.

1991 • 203 citations

CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

1991 • 184 citations

CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 179 citations

Soluble forms of CD40 inhibit biologic responses of human B cells.

1992 • 154 citations

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

1994 • 144 citations

Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer.

1994 • 85 citations

Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities

1994 • 66 citations

Protein Tyrosine Kinase Activation and Protein Kinase C Translocation Are Functional Components of CD40 Signal Transduction in Resting Human B Cells

1994 • 14 citations