Regulation of IκBβ Degradation

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

1994 • 302 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

N- and C-Terminal Sequences Control Degradation of MAD3/IκBα in Response to Inducers of NF-κB Activity

1995 • 227 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α

1996 • 182 citations

The IκB proteins: members of a multifunctional family

1993 • 169 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

1995 • 160 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

Prominent usage of V beta 8.3 T cells in the H-2Db-restricted response to an influenza A virus nucleoprotein epitope.

1993 • 150 citations

The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers

1995 • 122 citations

NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule

1993 • 106 citations

Inducible Degradation of IκBα In Vitro and In Vivo Requires the Acidic C-Terminal Domain of the Protein

1995 • 103 citations

A role for phosphorylation and degradation in the control of NF-κB activity

1995 • 99 citations

Purified I kappa B-beta is inactivated upon dephosphorylation.

1992 • 97 citations

Activation of NF-κB by Phosphatase Inhibitors Involves the Phosphorylation of IκBα at Phosphatase 2A-sensitive Sites

1995 • 96 citations

Identification of polypeptides whose presence correlates with retention or loss of an albumin extinguisher chromosome in rat hepatoma-mouse L cell fibroblast microcell hybrids

1994 • 8 citations