IκB-β regulates the persistent response in a biphasic activation of NF-κB

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.

1993 • 361 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB

1992 • 250 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner.

1993 • 242 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.

1991 • 210 citations

Proteolytic degradation of MAD3 (IϰBα) and enhanced processing of the NF-ϰB precursor p105 are obligatory steps in the activation of NF-ϰB

1993 • 194 citations

The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50.

1992 • 178 citations

The IκB proteins: members of a multifunctional family

1993 • 169 citations

The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.

1993 • 155 citations

The proto-oncogene bcl-3 encodes an I kappa B protein.

1992 • 116 citations

Purified I kappa B-beta is inactivated upon dephosphorylation.

1992 • 97 citations

A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.

1993 • 88 citations