Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

The Immunopathogenesis of Human Immunodeficiency Virus Infection

1993 • 1,194 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus

1991 • 394 citations

Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

1995 • 386 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

The macrophage in the persistence and pathogenesis of HIV infection

1989 • 365 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study

1989 • 297 citations

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

1993 • 242 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS

1994 • 235 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Rapid Loss of CD4 ⁺ T Cells in Human-PBL-SCID Mice by Noncytopathic HIV Isolates

1993 • 189 citations

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

1994 • 174 citations

Membrane tumour necrosis factor-α is involved in the polyclonal B-cell activation induced by HIV-infected human T cells

1993 • 147 citations

Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.

1990 • 127 citations

Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP.

1988 • 126 citations

Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells?

1994 • 112 citations

Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer

1994 • 111 citations

Regulation of apoptosis and T cell activation by Fas-specific mAb

1994 • 107 citations

Lack of T Cell Dysfunction and Programmed Cell Death in Human Immunodeficiency Virus Type 1-Infected Chimpanzees Correlates with Absence of Monocytotropic Variants

1993 • 105 citations

Ultrastructural Features of Epithelial Cell Degeneration in Rectal Crypts of Patients with AIDS

1986 • 99 citations

Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4

1993 • 94 citations

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion

1993 • 91 citations

Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1

1994 • 89 citations

Macrophage-tropic HIV: critical for AIDS pathogenesis?

1994 • 88 citations

The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells.

1990 • 87 citations

Effects of structure and chemical activity on the ability of nitrosoureas to inhibit DNA repair.

1980 • 61 citations

Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus

1995 • 59 citations

Monocytes are required to prime peripheral blood T cells to undergo apoptosis.

1995 • 57 citations

Programmed cell death (apoptosis) as a mechanism of cell death in peripheral blood mononuclear cells from cats infected with feline immunodeficiency virus (FIV)

1993 • 53 citations

Tumor necrosis factor alpha and soluble tumor necrosis factor receptors in individuals with human immunodeficiency virus infection

1994 • 53 citations

Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells.

1993 • 40 citations

Activation-Dependent Apoptosis in CD4+ T Cells during Murine AIDS

1993 • 23 citations

HIV-Induced T-Lymphocyte Depletion

1994 • 16 citations

Direct determination of the influence of the cell cycle on the survival of tumor cells exposed to cytotoxic antibodies.

1980 • 14 citations