Signal-Induced Degradation of IκBα: Association with NF-κB and the PEST Sequence in IκBα Are Not Required

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

1991 • 288 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.

1992 • 252 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.

1991 • 242 citations

N- and C-Terminal Sequences Control Degradation of MAD3/IκBα in Response to Inducers of NF-κB Activity

1995 • 227 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

Ablation of Transplanted HTLV-I Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-κB

1992 • 207 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

1995 • 183 citations

Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α

1996 • 182 citations

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.

1994 • 178 citations

Constitutive Phosphorylation of IκBα by Casein Kinase II Occurs Preferentially at Serine 293: Requirement for Degradation of Free IκBα

1996 • 164 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

1995 • 160 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

c-rel activates but v-rel suppresses transcription from kappa B sites.

1991 • 146 citations

Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

1992 • 140 citations

Domain Organization of IκBα and Sites of Interaction with NF-κB p65

1995 • 124 citations

The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers

1995 • 122 citations

Inducible Degradation of IκBα In Vitro and In Vivo Requires the Acidic C-Terminal Domain of the Protein

1995 • 103 citations

Molecular Cloning and Characterization of a Novel Rel/NF-χB Family Member Displaying Structural and Functional Homology to NF-χB p50/p105

1992 • 102 citations

Malignant transformation by mutant Rel proteins

1991 • 96 citations

Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

1993 • 92 citations

Cloning of a Differentially Expressed IκB-related Protein

1995 • 40 citations

Kappa B enhancer-binding complexes that do not contain NF-kappa B are developmentally regulated in mammalian brain.

1994 • 38 citations

The ankyrin repeats but not the PEST-like sequences are required for signal-dependent degradation of IkappaBalpha.

1996 • 30 citations

Diverse molecular mechanisms of inhibition of NF-kappa B/DNA binding complexes by I kappa B proteins.

1993 • 17 citations

Deleted Work

1955 • 0 citations