The regulation of E2F by pRB-family proteins

A Kinematic Notation for Lower-Pair Mechanisms Based on Matrices

1955 • 4,187 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Coordination of Growth and Cell Division in the Drosophila Wing

1998 • 760 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Regulation of cell proliferation by the E2F transcription factors

1998 • 486 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

1998 • 450 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Control of pRB phosphorylation

1998 • 389 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A

1997 • 379 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

1998 • 340 citations

The retinoblastoma gene family: cousins with overlapping interests

1998 • 337 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16^INK4A-Mediated Growth Suppression

1996 • 297 citations

RB and hbrm cooperate to repress the activation functions of E2F1

1997 • 293 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

1997 • 293 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

1997 • 284 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1997 • 266 citations

Oncogenes and cell death

1994 • 266 citations

A retinoblastoma-binding protein related to a negative regulator of Ras in yeast

1993 • 265 citations

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

1998 • 261 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1995 • 250 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter

1996 • 248 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

In Vivo Association of E2F and DP Family Proteins

1995 • 246 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

E2F and Cell Proliferation: A World Turned Upside Down

1996 • 234 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

1991 • 231 citations

Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

1995 • 229 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G₀ Cell State From a G₁ Cell State

1996 • 222 citations

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

1998 • 217 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals

1997 • 211 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins

1997 • 206 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization

1997 • 195 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

1998 • 190 citations

The Transcription Factor E2F-1 Is a Downstream Target of RB Action

1995 • 190 citations

A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor

1995 • 188 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting

1998 • 177 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

1995 • 165 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis

1994 • 160 citations

Mutations in Drosophila DP and E2F distinguish G₁–S progression from an associated transcriptional program

1997 • 157 citations

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.

1994 • 155 citations

Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.

1996 • 154 citations

Cell Cycle Regulation of E2F Site Occupation in Vivo

1996 • 152 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

1987 • 149 citations

A human protein related to yeast Cdc6p

1997 • 147 citations

Expression of the HsOrc1 Gene, a Human ORC1 Homolog, Is Regulated by Cell Proliferation via the E2F Transcription Factor

1996 • 145 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.

1993 • 141 citations

Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex.

1987 • 140 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1998 • 138 citations

Functional properties of a Drosophila homolog of the E2F1 gene.

1994 • 134 citations

Subunit Composition Determines E2F DNA-Binding Site Specificity

1997 • 132 citations

The retinoblastoma protein binds E2F residues required for activation in vivo and TBP bindingin vitro

1993 • 131 citations

Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

1996 • 120 citations

E2F-induced S phase requires cyclin E.

1996 • 119 citations

Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye.

1996 • 118 citations

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

1992 • 115 citations

The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter

1995 • 115 citations

Differential Roles of Two Tandem E2F Sites in Repression of the Human p107 Promoter by Retinoblastoma and p107 Proteins

1995 • 114 citations

Phosphorylation of E2F-1 by cyclin A-cdk2.

1995 • 109 citations

S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation

1997 • 107 citations

Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle

1996 • 107 citations

E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.

1996 • 104 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

Mutations of the Drosophila dDP,dE2F, and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G₁-S Transition

1998 • 100 citations

Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription

1995 • 98 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F

1993 • 94 citations

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

1995 • 92 citations

A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene

1993 • 91 citations

Transcriptional regulation of the dihydrofolate reductase gene

1996 • 89 citations

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

1995 • 85 citations

Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F

1992 • 82 citations

E2F-1 Blocks Terminal Differentiation and Causes Proliferation in Transgenic Megakaryocytes

1996 • 82 citations

Cyclin A/CDK2 Binds Directly to E2F-1 and Inhibits the DNA-Binding Activity of E2F-1/DP-1 by Phosphorylation

1994 • 81 citations

Cloning and characterization of human DP2, a novel dimerization partner of E2F.

1995 • 81 citations

Expression patterns of the E2F family of transcription factors during mouse nervous system development

1997 • 78 citations

E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest

1996 • 76 citations

p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB

1998 • 73 citations

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

1996 • 73 citations

Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function

1996 • 72 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1994 • 71 citations

E2F Mediates Dihydrofolate Reductase Promoter Activation and Multiprotein Complex Formation in Human Cytomegalovirus Infection

1992 • 68 citations

Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells.

1996 • 66 citations

Functional roles of E2F in cell cycle regulation

1997 • 66 citations

A Role for a Bent DNA Structure in E2F-Mediated Transcription Activation

1996 • 65 citations

Position-Dependent Transcriptional Regulation of the Murine Dihydrofolate Reductase Promoter by the E2F Transactivation Domain

1997 • 62 citations

The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells

1994 • 60 citations

A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F.

1995 • 58 citations

Functional Interaction between DP-1 and p53

1996 • 56 citations

Expression patterns of the E2F family of transcription factors during murine epithelial development.

1997 • 56 citations

Proto-oncogenic properties of the DP family of proteins.

1995 • 55 citations

An E2F dominant negative mutant blocks E1A induced cell cycle progression.

1994 • 55 citations

DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.

1996 • 49 citations

Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.

1993 • 42 citations

Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor

1997 • 37 citations

Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster

1995 • 33 citations

Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice.

1996 • 32 citations

E2Fs and the Retinoblastoma Protein Family

1997 • 31 citations

Promoter-dependent Photocross-linking of the Acidic Transcriptional Activator E2F-1 to the TATA-binding Protein

1995 • 30 citations

Expression of the E2F-1/DP-1 transcription factor in murine development.

1996 • 30 citations

Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F

1993 • 30 citations

Growth Regulation by the E2F and DP Transcription Factor Families

1998 • 26 citations

Transcriptional control of cell growth : the E2F gene family

1996 • 24 citations

Molecular characterization of Xenopus laevis DP proteins.

1994 • 24 citations

E2F and Its Developmental Regulation in Xenopus laevis

1994 • 24 citations

E2F and its developmental regulation in Xenopus laevis.

1994 • 14 citations

Transcriptional Control of Cell Growth

1996 • 9 citations

Isolation and characterization of a chicken homolog of the E2F-1 transcription factor.

1995 • 8 citations