Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1991 • 319 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

1995 • 253 citations

Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.

1994 • 251 citations

Nuclear localization signals (NLS).

1993 • 249 citations

In Vivo Association of E2F and DP Family Proteins

1995 • 246 citations

Mechanisms of nuclear protein import

1995 • 241 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins

1995 • 211 citations

Putative nuclear localization signals (NLS) in protein transcription factors

1994 • 199 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 177 citations

Transcriptional regulation during the mammalian cell cycle

1995 • 152 citations

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.

1992 • 137 citations

The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors

1993 • 135 citations

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

1995 • 135 citations

Alternative Forms of Max as Enhancers or Suppressors of Myc-Ras Cotransformation

1992 • 130 citations

Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localisation

1993 • 114 citations

The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

1989 • 107 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Nuclear transport

1994 • 89 citations

Cloning and characterization of human DP2, a novel dimerization partner of E2F.

1995 • 81 citations

A Protein Synthesis-Dependent Increase in E2F1 mRNA Correlates with Growth Regulation of the Dihydrofolate Reductase Promoter

1993 • 80 citations

A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F.

1995 • 58 citations

Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various numa isoforms

1994 • 58 citations

Proto-oncogenic properties of the DP family of proteins.

1995 • 55 citations

The two isoforms of mouse terminal deoxynucleotidyl transferase differ in both the ability to add N regions and subcellular localization.

1995 • 52 citations

Human papillomavirus type 16 E7 regulates E2F and contributes to mitogenic signalling.

1993 • 50 citations

Molecular and functional characterisation of E2F-5, a new member of the E2F family.

1995 • 43 citations

A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation.

1995 • 41 citations

Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F

1993 • 30 citations

Human foamy virus Bel1 transactivator contains a bipartite nuclear localization determinant which is sensitive to protein context and triple multimerization domains

1995 • 29 citations

Molecular characterization of Xenopus laevis DP proteins.

1994 • 24 citations

NF-κB: A Mediator of Pathogen and Stress Responses

1995 • 23 citations

Regulation of Nuclear Transport and Activity of the Drosophila Morphogen Dorsal

1995 • 3 citations