Retinoblastoma protein represses transcription by recruiting a histone deacetylase

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

1997 • 565 citations

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

1996 • 541 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Targeting Chromatin Disruption: Transcription Regulators that Acetylate Histones

1996 • 369 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Histone acetylation and control of gene expression

1991 • 331 citations

RB and hbrm cooperate to repress the activation functions of E2F1

1997 • 293 citations

RB kinases and RB-binding proteins: new points of view

1997 • 264 citations

E2F and Cell Proliferation: A World Turned Upside Down

1996 • 234 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.

1993 • 141 citations

The retinoblastoma gene and gene product.

1992 • 111 citations

Physical Interaction between the Mitogen-responsive Serum Response Factor and Myogenic Basic-Helix-Loop-Helix Proteins

1996 • 100 citations

Domains A and B in the Rb Pocket Interact To Form a Transcriptional Repressor Motif

1996 • 98 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

The Rb Family Contains a Conserved Cyclin-Dependent-Kinase-Regulated Transcriptional Repressor Motif

1996 • 67 citations

Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.

1996 • 30 citations