E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Principles of CDK regulation

1995 • 3,267 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle

1994 • 460 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

1993 • 389 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

1993 • 307 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 ^cdc2 Protein Kinase

1990 • 285 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.

1992 • 272 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

1995 • 244 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

1995 • 229 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

Role for cyclin A in the dependence of mitosis on completion of DMA replication

1991 • 212 citations

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

1990 • 209 citations

The retinoblastoma protein and the regulation of cell cycling

1992 • 198 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.

1995 • 186 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

G1 control in mammalian cells

1994 • 154 citations

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

1994 • 150 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

1994 • 130 citations

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.

1993 • 118 citations

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1

1993 • 113 citations

Identification of distinct roles for separate E1A domains in disruption of E2F complexes.

1993 • 113 citations

E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions.

1994 • 102 citations

Cyclins A and B1 in the Human Cell Cycle

2007 • 74 citations

Exploring the Role of Drosophila Cyclin A in the Regulation of S Phase

1991 • 47 citations

Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1.

1994 • 45 citations