Distinct roles for E2F proteins in cell growth control and apoptosis

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Mammalian G1 cyclins

1993 • 1,990 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Braking the cycle

1993 • 378 citations

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

1996 • 362 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G₀ Cell State From a G₁ Cell State

1996 • 222 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis

1994 • 160 citations

Expression of the HsOrc1 Gene, a Human ORC1 Homolog, Is Regulated by Cell Proliferation via the E2F Transcription Factor

1996 • 145 citations

[70] Definition and mapping of adenovirus 2 nuclear transcription

1980 • 136 citations

The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors

1993 • 135 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity.

1995 • 74 citations

Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F

1993 • 30 citations