Multifunctional strands in tight junctions

Integrin Signaling

1999 • 3,705 citations

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

2000 • 1,118 citations

Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg ²⁺ Resorption

1999 • 1,107 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

1999 • 1,094 citations

FRACTURE FACES OF ZONULAE OCCLUDENTES FROM "TIGHT" AND "LEAKY" EPITHELIA

1973 • 1,086 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Endothelial Claudin

1999 • 802 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

1999 • 724 citations

CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice

1999 • 678 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

Occludin is a functional component of the tight junction

1996 • 632 citations

Occludin as a possible determinant of tight junction permeability in endothelial cells

1997 • 626 citations

Barrier function of epithelia

1981 • 616 citations

Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands

1999 • 609 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

1997 • 576 citations

Occludin and claudins in tight-junction strands: leading or supporting players?

1999 • 575 citations

Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula Occludens

1978 • 569 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

1998 • 532 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS

1998 • 526 citations

Sec6/8 Complex Is Recruited to Cell–Cell Contacts and Specifies Transport Vesicle Delivery to the Basal-Lateral Membrane in Epithelial Cells

1998 • 523 citations

Human junction adhesion molecule regulates tight junction resealing in epithelia

2000 • 521 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Structure, function, and regulation of cellular tight junctions

1992 • 517 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

Further observations on the fine structure of freeze-cleaved tight junctions

1973 • 501 citations

Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer.

2000 • 486 citations

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

2000 • 469 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

Pores in the Wall

2000 • 451 citations

The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells.

1986 • 446 citations

Claudins regulate the intestinal barrier in response to immune mediators

2000 • 438 citations

The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

2000 • 437 citations

Mutations in the Gene Encoding Tight Junction Claudin-14 Cause Autosomal Recessive Deafness DFNB29

2001 • 436 citations

Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

1999 • 434 citations

Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1

2000 • 426 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Breaking through the tight junction barrier.

1993 • 379 citations

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

2000 • 378 citations

Membrane asymmetry in epithelia: is the tight junction a barrier to diffusion in the plasma membrane?

1981 • 350 citations

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

1998 • 349 citations

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

1996 • 329 citations

Structural and signalling molecules come together at tight junctions

1999 • 306 citations

Characterization of ZO-2 as a MAGUK Family Member Associated with Tight as well as Adherens Junctions with a Binding Affinity to Occludin and α Catenin

1999 • 302 citations

Cingulin Contains Globular and Coiled-Coil Domains and Interacts with Zo-1, Zo-2, Zo-3, and Myosin

1999 • 294 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Mammalian occludin in epithelial cells: its expression and subcellular distribution.

1997 • 278 citations

Evidence for the lipidic nature of tight junction strands

1982 • 277 citations

Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ

2000 • 276 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin

1997 • 272 citations

Restoration of Tight Junction Structure and Barrier Function by Down-Regulation of the Mitogen-activated Protein Kinase Pathway in Ras-transformed Madin-Darby Canine Kidney Cells

2000 • 271 citations

Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase

2000 • 267 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Structure of tight junctions in epithelia with different permeability.

1975 • 247 citations

Vascular Endothelial Junction-associated Molecule, a Novel Member of the Immunoglobulin Superfamily, Is Localized to Intercellular Boundaries of Endothelial Cells

2000 • 239 citations

Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance.

1988 • 238 citations

Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin

2000 • 229 citations

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

1994 • 228 citations

Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells: polarity of an apical protein is independent of tight junctions while segregation of a basolateral marker requires cell-cell interactions

1987 • 226 citations

Regulation of Cell Surface Polarity from Bacteria to Mammals

1992 • 221 citations

Tight junction dynamics: Is paracellular transport regulated?

1988 • 213 citations

Redistribution of surface macromolecules in dissociated epithelial cells.

1976 • 202 citations

MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains

1997 • 196 citations

Ca2+-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions

1999 • 195 citations

Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells

2000 • 195 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

ROUTES AND MECHANISM OF FLUID TRANSPORT BY EPITHELIA

1998 • 177 citations

Redistribution of membrane proteins in isolated mouse intestinal epithelial cells.

1980 • 163 citations

Lack of correlation between tight junction morphology and permeability properties in developing choroid plexus

1976 • 162 citations

Homophilic Interaction of Junctional Adhesion Molecule

2000 • 153 citations

Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes

1998 • 141 citations

Transbilayer phospholipid asymmetry and its maintenance in the membrane of influenza virus

1976 • 133 citations

Association of Junctional Adhesion Molecule with Calcium/calmodulin-dependent Serine Protein Kinase (CASK/LIN-2) in Human Epithelial Caco-2 Cells

2001 • 129 citations

Localization of membrane-associated guanylate kinase (MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cells

1999 • 128 citations

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

1991 • 120 citations

huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell–cell tight junctions

2000 • 114 citations

Occludin 1B, a Variant of the Tight Junction Protein Occludin

2000 • 111 citations

Identification, Characterization, and Precise Mapping of a Human Gene Encoding a Novel Membrane-Spanning Protein from the 22q11 Region Deleted in Velo–Cardio–Facial Syndrome

1997 • 103 citations

Plasma membrane and mucosal glycosphingolipids in the rat intestine

1973 • 98 citations

Isolation and characterization of a novel oligodendrocyte-specific protein

1996 • 93 citations

Involvement of Gαi2 in the Maintenance and Biogenesis of Epithelial Cell Tight Junctions

1998 • 85 citations

Cloning of JAM-2 and JAM-3: an Emerging Junctional Adhesion Molecular Family

2000 • 80 citations

Synaptic PDZ domain-containing proteins

1998 • 79 citations

Tight Junction: Barrier Between Higher Organisms and Environment

1989 • 51 citations

Phospholipids and cholesterol in brush border and basolateral membranes from rat intestinal mucosa

1983 • 40 citations

Phospholipid topology and flip-flop in intestinal brush-border membrane

1986 • 25 citations