T Cell Tolerance to a Neo-Self Antigen Expressed by Thymic Epithelial Cells: The Soluble Form Is More Effective Than the Membrane-Bound Form

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance

2002 • 243 citations

Mapping the antigenic epitope for a monoclonal antibody against lysozyme.

1982 • 202 citations

Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft".

1998 • 189 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Cutting Edge: Multiple Mechanisms of Peripheral T Cell Tolerance to the Fetal “Allograft”

1998 • 160 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection

1999 • 103 citations

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

2001 • 98 citations

Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1997 • 95 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells

1999 • 83 citations

T-cell tolerance

1993 • 55 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites

1996 • 40 citations

Immunotolerance against a foreign antigen transgenically expressed in the lens.

1998 • 37 citations

On the intrathymic intercellular transfer of self-determinants

1999 • 29 citations

Uveitis induced by lymphocytes sensitized against a transgenically expressed lens protein.

1999 • 17 citations

Breakdown of Tolerance to a Neo-Self Antigen in Double Transgenic Mice in Which B Cells Present the Antigen

2000 • 15 citations

T Cell Tolerance and the Thymus^a

1998 • 14 citations

Response to 'Lymphoid organs contain diverse cells expressing self-molecules'

2002 • 2 citations