Deciphering and Reversing Tumor Immune Suppression

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Comprehensive molecular portraits of human breast tumours

2012 • 10,753 citations

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

2012 • 7,361 citations

Cancer Genome Landscapes

2013 • 7,174 citations

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Human mesenchymal stem cells modulate allogeneic immune cell responses

2004 • 4,360 citations

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

2011 • 4,304 citations

Coordinated regulation of myeloid cells by tumours

2012 • 3,227 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

How regulatory T cells work

2008 • 3,048 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Dendritic Cells

2001 • 2,164 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Tumour necrosis factor and cancer

2009 • 1,712 citations

The role of myeloid cells in the promotion of tumour angiogenesis

2008 • 1,574 citations

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

2006 • 1,366 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺T lymphocytes are prognostic factors of human ovarian cancer

2007 • 1,317 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

2003 • 1,255 citations

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

2011 • 1,191 citations

The role of nitric oxide in tumour progression

2006 • 1,181 citations

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 • 1,175 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

2008 • 1,071 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

2013 • 1,019 citations

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

2009 • 1,000 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

2005 • 972 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival

2011 • 855 citations

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

2006 • 798 citations

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

2013 • 796 citations

Exploiting the Mutanome for Tumor Vaccination

2012 • 762 citations

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

2009 • 736 citations

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

2012 • 728 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

PD‐1 signaling in primary T cells

2009 • 712 citations

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

2006 • 705 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis

2011 • 648 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Molecular biology and biochemistry of the endothelins

1989 • 620 citations

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1997 • 615 citations

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

2007 • 614 citations

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

2005 • 606 citations

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

2011 • 585 citations

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

2011 • 583 citations

Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

1998 • 576 citations

The endothelin axis: emerging role in cancer

2003 • 559 citations

Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice

1998 • 552 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

2007 • 506 citations

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

1999 • 499 citations

Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention

2005 • 474 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.

1999 • 452 citations

Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β

2007 • 438 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

The parallel lives of angiogenesis and immunosuppression: cancer and other tales

2011 • 435 citations

Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A

2004 • 430 citations

A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-β1 Mediates Suppression in the Tumor Microenvironment

2007 • 429 citations

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

2008 • 426 citations

Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a

2001 • 418 citations

Epitope Landscape in Breast and Colorectal Cancer

2008 • 408 citations

High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

2007 • 403 citations

Dual targeting strategies with bispecific antibodies

2012 • 396 citations

A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

2005 • 390 citations

Immature, but not inactive: the tolerogenic function of immature dendritic cells

2002 • 389 citations

TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells.

1999 • 379 citations

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers

2005 • 377 citations

HLA-G Molecules: from Maternal–Fetal Tolerance to Tissue Acceptance

2003 • 370 citations

In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor

2007 • 362 citations

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

2003 • 361 citations

Dendritic Cell and Macrophage Heterogeneity In Vivo

2011 • 354 citations

Endothelin-1 Induces an Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

2000 • 334 citations

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors

2011 • 316 citations

B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

2002 • 313 citations

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

2001 • 307 citations

MHC class Ib molecules bridge innate and acquired immunity

2005 • 307 citations

TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells

1999 • 303 citations

Specific Recruitment of CC Chemokine Receptor 4–Positive Regulatory T Cells in Hodgkin Lymphoma Fosters Immune Privilege

2006 • 295 citations

The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

2008 • 294 citations

Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation

1994 • 283 citations

Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium

1996 • 281 citations

Activation of MHC Class I, II, and CD40 Gene Expression by Histone Deacetylase Inhibitors

2000 • 279 citations

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

2011 • 279 citations

Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

2011 • 276 citations

Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors.

1996 • 268 citations

Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression.

2003 • 267 citations

IDO and tolerance to tumors

2003 • 262 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c‐Jun activation

2011 • 253 citations

Tumor-Induced Expansion of Regulatory T Cells by Conversion of CD4+CD25− Lymphocytes Is Thymus and Proliferation Independent

2006 • 252 citations

Hypoxia controls CD4⁺CD25⁺ regulatory T‐cell homeostasis via hypoxia‐inducible factor‐1α

2008 • 243 citations

Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen

2005 • 243 citations

Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice

1999 • 232 citations

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy

1999 • 223 citations

Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization

2004 • 221 citations

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

2010 • 217 citations

TNFα regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation

1998 • 215 citations

Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

2011 • 209 citations

Interleukin‐10 expressed at early tumour sites induces subsequent generation of CD4⁺ T‐regulatory cells and systemic collapse of antitumour immunity

2001 • 206 citations

Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

1999 • 205 citations

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

2011 • 199 citations

A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism

2007 • 198 citations

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

2009 • 198 citations

Endothelin-1 Induces Vascular Endothelial Growth Factor by Increasing Hypoxia-inducible Factor-1α in Ovarian Carcinoma Cells

2002 • 198 citations

Tumor-Infiltrating γδ T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

2012 • 198 citations

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

2011 • 193 citations

Cytokine Levels Correlate with Immune Cell Infiltration after Anti-VEGF Therapy in Preclinical Mouse Models of Breast Cancer

2009 • 185 citations

The endothelin axis in cancer

2008 • 182 citations

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

2012 • 181 citations

Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses

2007 • 177 citations

Effects of Vascular Endothelial Growth Factor on the Lymphocyte-Endothelium Interactions: Identification of Caveolin-1 and Nitric Oxide as Control Points of Endothelial Cell Anergy

2007 • 176 citations

Depletion of Plasmacytoid Dendritic Cells Inhibits Tumor Growth and Prevents Bone Metastasis of Breast Cancer Cells

2012 • 176 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Synergy between tumor immunotherapy and antiangiogenic therapy

2003 • 167 citations

Antigens for cancer immunotherapy

2008 • 166 citations

Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal Cell Carcinoma

2007 • 161 citations

Tumor-induced death of immune cells: its mechanisms and consequences

2002 • 154 citations

Defective Function of Langerhans Cells in Tumor-Bearing Animals Is the Result of Defective Maturation from Hemopoietic Progenitors

1998 • 154 citations

Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion

2010 • 151 citations

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4+CD25+ regulatory T cells

2007 • 150 citations

IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice

2007 • 148 citations

Endothelium-derived factors as paracrine mediators of prostate cancer progression

2000 • 136 citations

Tumor-Derived Chemokine MCP-1/CCL2 Is Sufficient for Mediating Tumor Tropism of Adoptively Transferred T Cells

2007 • 133 citations

Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration

2007 • 131 citations

Tumor immune escape by the loss of homeostatic chemokine expression

2007 • 131 citations

NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells

2012 • 126 citations

Hepatocyte Growth Factor Suppresses Vascular Endothelial Growth Factor-Induced Expression of Endothelial ICAM-1 and VCAM-1 by Inhibiting the Nuclear Factor-κB Pathway

2005 • 123 citations

Roberto Martínez Martínez

2011 • 118 citations

PGE2 transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells

2010 • 115 citations

Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity

2008 • 111 citations

Classical and Nonclassical HLA Class I Antigen and NK Cell–Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions

2005 • 110 citations

Vascular endothelial growth factor inhibits maturation of dendritic cells induced by lipopolysaccharide, but not by proinflammatory cytokines

2004 • 110 citations

Characterization of Endocrine Gland-derived Vascular Endothelial Growth Factor Signaling in Adrenal Cortex Capillary Endothelial Cells

2002 • 109 citations

Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma.

2003 • 106 citations

Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma.

2003 • 105 citations

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile

2008 • 96 citations

Dendritic Cells and Vascular Endothelial Growth Factor in Colorectal Cancer: Correlations with Clinicobiological Findings

2005 • 91 citations

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.

2003 • 91 citations

The functional role of cell adhesion molecules in tumor angiogenesis

2009 • 88 citations

Endothelin-1 and Endothelin-3 Promote Invasive Behavior via Hypoxia-Inducible Factor-1α in Human Melanoma Cells

2007 • 87 citations

Immunotherapy: target the stroma to hit the tumor

2005 • 86 citations

Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain Tumors

2009 • 73 citations

Independent Regulation of Chemokine Responsiveness and Cytolytic Function versus CD8+ T Cell Expansion by Dendritic Cells

2009 • 73 citations

The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences

2012 • 72 citations

Targeting stroma to treat cancers

2011 • 71 citations

Dendritic Cells and CD28 Costimulation Are Required To Sustain Virus-Specific CD8+ T Cell Responses during the Effector Phase In Vivo

2011 • 69 citations

Vascular Endothelial Expression of Indoleamine 2,3-Dioxygenase 1 Forms a Positive Gradient towards the Feto-Maternal Interface

2011 • 65 citations

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

2010 • 61 citations

Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions

2009 • 53 citations

The ovarian endothelin network: an evolving story

2007 • 50 citations

Tumor immune surveillance and ovarian cancer

2011 • 49 citations

Tumors induce the formation of suppressor endothelial cells in vivo

2009 • 45 citations

Chapter 1 Isolation, Identification, and Production of Posttranslationally Modified Chemokines

2009 • 39 citations

Angiogenesis as a predictor of long-term survival for 377 Japanese patients with breast cancer

2001 • 37 citations

Potential functional role of plasmacytoid dendritic cells in cancer immunity

2007 • 37 citations

TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2–Expressing Monocytes in Human Breast Tumors

2013 • 37 citations

Expression and function of ETA and ETB receptors in SSc

2008 • 23 citations

Arginine depletion as a mechanism for the immune privilege of corneal allografts

2011 • 18 citations