Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

2002 • 5,109 citations

Nitric oxide and the immune response

2001 • 3,222 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Arginine metabolism: nitric oxide and beyond

1998 • 2,697 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 • 834 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

2003 • 751 citations

The role of nitric oxide in cancer

2002 • 749 citations

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1997 • 680 citations

Adoptive-cell-transfer therapy for the treatment of patients with cancer

2003 • 656 citations

Inflammation and necrosis promote tumour growth

2004 • 646 citations

Cancer vaccines: between the idea and the reality

2003 • 616 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

Biological selectivity and functional aspects of protein tyrosine nitration

2003 • 501 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

Pathobiology of autochthonous prostate cancer in a pre‐clinical transgenic mouse model

2003 • 439 citations

Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going?

2002 • 400 citations

Inducible Nitric-oxide Synthase Generates Superoxide from the Reductase Domain

1998 • 389 citations

A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells

1991 • 381 citations

Tumor‐specific shared antigenic peptides recognized by human T cells

2002 • 371 citations

Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

2004 • 366 citations

NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?

2003 • 361 citations

Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

2001 • 353 citations

TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response

2004 • 334 citations

Blocking NO synthesis: how, where and why?

2002 • 323 citations

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

1999 • 307 citations

Peroxynitrite rapidly permeates phospholipid membranes

1997 • 299 citations

Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.

2001 • 289 citations

Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.

2002 • 258 citations

Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma

1994 • 257 citations

Arginases I and II: do their functions overlap?

2004 • 230 citations

Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma

2004 • 209 citations

Peroxynitrite: reactive, invasive and enigmatic

1999 • 209 citations

Delivering the kiss of death

2003 • 192 citations

Dynamics of protein nitration in cells and mitochondria

2004 • 189 citations

Rapid and Selective Oxygen-regulated Protein Tyrosine Denitration and Nitration in Mitochondria

2004 • 177 citations

Signaling defects in T lymphocytes of patients with malignancy

1999 • 166 citations

CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis

2001 • 153 citations

Growth of tumor-infiltrating lymphocytes from human solid cancers: Summary of a 5-year experience

1996 • 151 citations

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.

1987 • 128 citations

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

2000 • 125 citations

Classical and Slow-Binding Inhibitors of Human Type II Arginase

2001 • 103 citations

Inducible nitric oxide synthase (iNOS) expression and its prognostic value in prostate cancer.

2001 • 101 citations

T-cell responses of vaccinated cancer patients

2003 • 93 citations

Cytotoxicity and apoptosis in human renal allografts: identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA.

1997 • 90 citations

In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation

2001 • 88 citations

Cancer-induced Defective Cytotoxic T Lymphocyte Effector Function: Another Mechanism How Antigenic Tumors Escape Immune-mediated Killing

2000 • 78 citations

Denitration of peroxynitrite-treated proteins by 'protein nitratases' from rat brain and heart.

1999 • 70 citations

Immune Cells in the Tumor Microenvironment

1998 • 64 citations

Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects.

1998 • 64 citations

CD8+ Tumor-Infiltrating Lymphocytes Are Primed for Fas-Mediated Activation-Induced Cell Death But Are Not Apoptotic In Situ

2001 • 58 citations

Science, medicine, and the future: Cellular immunotherapy for cancer

2001 • 57 citations

Expression of inducible nitric oxide synthase in paired neoplastic and non-neoplastic primary prostate cell cultures and prostatectomy specimen

2003 • 51 citations

Possible implications of arginase and diamine oxidase in prostatic carcinoma.

2001 • 48 citations

Arginase Activity is Inhibited by l -NAME, both In Vitro and In Vivo

2002 • 36 citations

Characteristics of nonmalignant and malignant human prostate in organ culture.

1999 • 23 citations

A parathyroid-hormone-related-protein (PTH-rP)-specific cytotoxic T cell response induced by in vitro stimulation of tumour-infiltrating lymphocytes derived from prostate cancer metastases, with epitope peptide-loaded autologous dendritic cells and low-dose IL-2

2001 • 18 citations

Immunosensitization of resistant human tumor cells to cytotoxicity by tumor infiltrating lymphocytes

2003 • 17 citations