Endothelin-1 Induces Vascular Endothelial Growth Factor by Increasing Hypoxia-inducible Factor-1α in Ovarian Carcinoma Cells

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

HIF-1 and mechanisms of hypoxia sensing

2001 • 1,131 citations

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

2000 • 784 citations

Endothelins

1995 • 682 citations

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1999 • 645 citations

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

2000 • 641 citations

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

1997 • 605 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells

2000 • 465 citations

The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.

2000 • 452 citations

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

2000 • 421 citations

Activation of the HIF pathway in cancer

2001 • 403 citations

Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels

1997 • 356 citations

Endothelin-1 Induces an Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

2000 • 334 citations

Molecular Regulation of the Endothelin-1 Gene by Hypoxia

2001 • 333 citations

Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.

2001 • 309 citations

Angiotensin II Increases Vascular Permeability Factor Gene Expression by Human Vascular Smooth Muscle Cells

1995 • 299 citations

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

2001 • 245 citations

The von Hippel–Lindau tumor suppressor protein

2001 • 208 citations

Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

1999 • 205 citations

Vasoactive Peptides Modulate Vascular Endothelial Cell Growth Factor Production and Endothelial Cell Proliferation and Invasion

1997 • 205 citations

Role of Endothelin-1 in Neovascularization of Ovarian Carcinoma

2000 • 188 citations

Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells.

2001 • 160 citations

Endothelin-1 Protects Ovarian Carcinoma Cells against Paclitaxel-Induced Apoptosis: Requirement for Akt Activation

2002 • 136 citations

Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells.

1997 • 120 citations

Hypoxia: the tumor's gateway to progression along the angiogenic pathway

2001 • 120 citations

Induction of Vascular Endothelial Growth Factor Expression and Hypoxia-inducible Factor 1α Protein by the Oxidative Stressor Arsenite

2001 • 117 citations

Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension

2001 • 109 citations

Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells.

1995 • 105 citations

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap

2001 • 94 citations

Hypoxia: the tumor's gateway to progression along the angiogenic pathway

2001 • 90 citations

Modulation of Human Colon Tumor-Stromal Interactions by the Endothelin System

2000 • 76 citations

Endothelin-1, a Regulator of Angiogenesis in the Chick Chorioallantoic Membrane

2001 • 56 citations

Maple syrup urine disease in Mennonites. Evidence that the Y393N mutation in E1 alpha impedes assembly of the E1 component of branched-chain alpha-keto acid dehydrogenase complex.

1991 • 42 citations

Deleted Work

1955 • 0 citations