Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

1997 • 1,179 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Fundamental Immunology

1994 • 903 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Modulation of Macrophage Function by Transforming Growth Factor ?, Interleukin-4, and Interleukin-10

1993 • 393 citations

Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma

1997 • 384 citations

IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response.

1995 • 326 citations

Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.

1994 • 314 citations

Interleukin-10

1992 • 303 citations

Altered Immune Responses in Interleukin 10 Transgenic Mice

1997 • 279 citations

The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

1992 • 273 citations

Production of IL‐10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma

1994 • 248 citations

Interleukin‐10 production by human carcinoma cell lines and its relationship to interleukin‐6 expression

1993 • 245 citations

Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.

1993 • 241 citations

Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.

1992 • 235 citations

Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.

1996 • 227 citations

Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.

1988 • 226 citations

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity

1992 • 210 citations

Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice.

1996 • 207 citations

Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells.

1997 • 200 citations

Relation between Langerhans Cells, Veiled Cells, and Interdigitating Cells

1982 • 194 citations

IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells.

1995 • 194 citations

Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.

1995 • 190 citations

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory.

1995 • 180 citations

Expression of interleukin 10 in human melanoma

1994 • 147 citations

Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma

1995 • 138 citations

Production of interleukin-10 by human bronchogenic carcinoma.

1994 • 119 citations

Interleukin-10 production in malignant melanoma: Preferential detection of IL-10-secreting tumor cells in metastatic lesions

1996 • 105 citations

Migration Patterns of Dendritic cells in the Mouse

1988 • 105 citations

CD8 T cell clones inhibit antitumor T cell function by secreting IL-10.

1995 • 104 citations

Signals arising from antigen-presenting cells

1991 • 100 citations

Loss of Tumorigenicity and Increased Immunogenicity Induced by Interleukin-10 Gene Transfer in B16 Melanoma Cells

1996 • 83 citations

IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression.

1995 • 73 citations

Expression of cytokine mRNA in human melanoma tissues

1995 • 73 citations

Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under FCS-free conditions: effect of culture conditions on the type of T cell response

1997 • 8 citations

Deleted Work

1955 • 0 citations