Back to search

High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

Data up to Jan 2025

Published2007
Citations403
References53
Clinical Trials (1)

Total Citations Per Year

Abstract

References (53)

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

2003 • 6,072 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Papillomaviruses and cancer: from basic studies to clinical application

2002 • 3,873 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Intraepithelial CD8+tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 • 1,175 citations

Chapter 1: Human Papillomavirus and Cervical Cancer--Burden and Assessment of Causality

2003 • 818 citations

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

2006 • 677 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive.

2000 • 314 citations

Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6

2004 • 311 citations

Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

2005 • 262 citations

Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells

2003 • 232 citations

Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis

2004 • 214 citations

Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.

2003 • 211 citations

Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma

2004 • 209 citations

Infiltration of cervical cancer tissue with human papilloma virus-specific cytotoxic T-lymphocytes

1997 • 196 citations

Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A *0201-restricted E7-encoded epitope.

1996 • 180 citations

Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX? adjuvant in women with cervical intraepithelial neoplasia

2004 • 178 citations

Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins.

2003 • 171 citations

Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia.

2003 • 168 citations

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.

2002 • 152 citations

Natural T-helper immunity against human papillomavirus type 16 (hpv16) e7-derived peptide epitopes in patients with hpv16-positive cervical lesions: Identification of 3 human leukocyte antigen class ii-restricted epitopes

2001 • 145 citations

Immunological Responses in Women with Human Papillomavirus Type 16 (HPV-16)-Associated Anogenital Intraepithelial Neoplasia Induced by Heterologous Prime-Boost HPV-16 Oncogene Vaccination

2004 • 127 citations

Histopathologic parameters of prognosis in cervical cancer - a review

2004 • 107 citations

Human papillomavirus detection in paraffin-embedded cervical carcinomas and metastases of the carcinomas by the polymerase chain reaction.

1989 • 91 citations

Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia

2000 • 87 citations

CD8hi+CD57+ T lymphocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity

1998 • 81 citations

Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: a prognostic study

1996 • 80 citations

Detection of human papillomavirus type 18 E6 and E7‐specific CD4+ T‐helper 1 immunity in relation to health versus disease

2005 • 76 citations

Infiltration of cervical cancer tissue with human papilloma virus-specific cytotoxic T-lymphocytes

1997 • 71 citations

Proliferative T cell responses to the human papillomavirus type 16 E7 protein in women with cervical dysplasia and cervical carcinoma and in healthy individuals

1996 • 68 citations

Isolation and characterization of tumor‐infiltrating lymphocytes from cervical carcinoma

1994 • 66 citations

Adjuvant radiotherapy following radical hysterectomy for patients with early-stage cervical carcinoma (1984-1996)

1999 • 57 citations

CD4+ Tumor-Infiltrating Lymphocytes in Cervical Cancer Recognize HLA-DR-Restricted Peptides Provided by Human Papillomavirus-E7

1999 • 50 citations

The case for completing the lymphadenectomy when positive lymph nodes are found during radical hysterectomy for cervical carcinoma

2000 • 50 citations

Identification of a Conserved Universal Th Epitope in HIV-1 Reverse Transcriptase That Is Processed and Presented to HIV-Specific CD4+ T Cells by at Least Four Unrelated HLA-DR Molecules

1999 • 48 citations

Human Papillomavirus Type 33 E7 Peptides Presented by HLA-DR*0402 to Tumor-Infiltrating T Cells in Cervical Cancer

2000 • 38 citations

Lymphocyte-infiltrated FIGO Stage IIB squamous cell carcinoma of the cervix is a prominent factor for disease-free survival.

1999 • 37 citations

A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer

2003 • 35 citations

The case for completing the lymphadenectomy when positive lymph nodes are found during radical hysterectomy for cervical carcinoma

2000 • 30 citations

The status of HPV16-specific T-cell reactivity in health and disease as a guide to HPV vaccine development

2002 • 30 citations

Histopathologic parameters of prognosis in cervical cancer – a review

2004 • 28 citations

Magnitude and polarization of P53‐specific T‐helper immunity in connection to leukocyte infiltration of colorectal tumors

2003 • 28 citations

Induction of tumor-specific cytotoxicity in tumor infiltrating lymphocytes by HPV16 and HPV18 E7-pulsed autologous dendritic cells in patients with cancer of the uterine cervix

2003 • 27 citations

Rapid enrichment of human papillomavirus (HPV)‐specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer

2004 • 23 citations

Correlation of three-dimensional tumor volumetry with cervical cancer prognostic parameters.

2002 • 20 citations

Four-color staining combining fluorescence and brightfield microscopy for simultaneous immune cell phenotyping and localization in tumor tissue sections

2005 • 15 citations

Adjuvant therapy after primary surgery for stage I-IIA carcinoma of the cervix.

1996 • 15 citations

CTL-mediated immunity against human papillomavirus type 16 E7-encoded epitopes presented by HLA-A2

1997 • 6 citations

Deleted Work

1955 • 0 citations

Cited By (0)

No citing papers found in database

High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the… (2007) – Cancer Research | Metascience Observatory Explorer