The ovarian endothelin network: an evolving story

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology*

2001 • 984 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Endothelin System: The Double-Edged Sword in Health and Disease

2001 • 730 citations

The endothelin axis: emerging role in cancer

2003 • 559 citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

1998 • 488 citations

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology

2001 • 441 citations

Endothelin-1 Induces an Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

2000 • 334 citations

Contrasting Actions of Endothelin ET_Aand ET_BReceptors in Cardiovascular Disease

2006 • 278 citations

Endothelin receptors and calcium signaling ¹

1995 • 269 citations

Historical review: Endothelin

2004 • 257 citations

Regulation and Intracellular Trafficking Pathways of the Endothelin Receptors

2000 • 243 citations

Cellular composition of the cyclic corpus luteum of the cow

1989 • 233 citations

Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)

1994 • 200 citations

Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development

2000 • 190 citations

Endothelin-1: a multifunctional molecule in cancer

2003 • 179 citations

A fourth isoform of endothelin‐converting enzyme (ECE‐1) is generated from an additional promoter

1999 • 169 citations

Endothelin-1 Protects Ovarian Carcinoma Cells against Paclitaxel-Induced Apoptosis: Requirement for Akt Activation

2002 • 136 citations

Effect of endothelin-1 on bovine luteal cell function: role in prostaglandin F2alpha-induced antisteroidogenic action.

1996 • 132 citations

Regulation of endothelin-1 expression in the bovine corpus luteum: elevation by prostaglandin F 2 alpha.

1996 • 129 citations

Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.

2000 • 127 citations

Endothelin-2 in Ovarian Follicle Rupture

2006 • 124 citations

Real-Time Relationships between Intraluteal and Plasma Concentrations of Endothelin, Oxytocin, and Progesterone during Prostaglandin F2α ,-Induced Luteolysis in the Cow1

1998 • 109 citations

Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.

1991 • 109 citations

Administration of Prostaglandin F2α During the Early Bovine Luteal Phase Does Not Alter the Expression of ET-1 and of Its Type A Receptor: A Possible Cause for Corpus Luteum Refractoriness

2000 • 107 citations

A Novel Pathway Involving Progesterone Receptor, Endothelin-2, and Endothelin Receptor B Controls Ovulation in Mice

2006 • 102 citations

A Role for Endothelin-2 and Its Receptors in Breast Tumor Cell Invasion

2004 • 101 citations

Intraovarian regulation of luteolysis.

1999 • 100 citations

Endothelin-1 Mediates Prostaglandin F2α-Induced Luteal Regression in the Ewe1

2001 • 88 citations

Role of EGF Receptor and Pyk2 in Endothelin-1-induced ERK Activation in Rat Cardiomyocytes

2002 • 87 citations

Emerging role of the endothelin axis in ovarian tumor progression

2005 • 85 citations

Cellular Distribution of Endothelin-converting Enzyme-1 in Human Tissues

1999 • 84 citations

Heterodimerization of Endothelin-converting Enzyme-1 Isoforms Regulates the Subcellular Distribution of This Metalloprotease

2002 • 83 citations

Regulation of Phospholipases C and D in Rat Ventricular Myocytes: Stimulation by Endothelin-1, Bradykinin and Phenylephrine

1997 • 67 citations

Characterization of endothelin-1 and nitric oxide generating systems in corpus luteum-derived endothelial cells

2004 • 64 citations

Inter-relationships between endothelin and prostaglandin F2alpha in corpus luteum function

2000 • 63 citations

Endothelins Inhibit Luteinization of Cultured Porcine Granulosa Cells*

1991 • 63 citations

Angiogenic activity of bovine corpora lutea at several stages of luteal development

1988 • 60 citations

Mechanisms of Endothelin Receptor Subtype-specific Targeting to Distinct Intracellular Trafficking Pathways

2001 • 55 citations

The Expression of Angiotensin and Endothelin System Members in Bovine Corpus Luteum During Estrous Cycle and Pregnancy

2002 • 53 citations

Prostaglandin F2α Regulation of the Bovine Corpus Luteum Endothelin System During the Early and Midluteal Phase1

2001 • 51 citations

Effect of endothelins on the cardiovascular system

2006 • 51 citations

Effect of endothelin-1 on bovine luteal cell function: role in prostaglandin F2alpha-induced antisteroidogenic action

1996 • 50 citations

Regulation of endothelin-1 expression in the bovine corpus luteum: elevation by prostaglandin F 2 alpha

1996 • 50 citations

Constitutive Lysosomal Targeting and Degradation of Bovine Endothelin-converting Enzyme-1a Mediated by Novel Signals in Its Alternatively Spliced Cytoplasmic Tail

1999 • 50 citations

Plasma endothelin-1 level is related to renal function and smoking status but not to blood pressure

2004 • 49 citations

Vasoactive peptides in cardiovascular (patho)physiology

2007 • 47 citations

Distinct Cellular Localization and Regulation of Endothelin-1 and Endothelin-Converting Enzyme-1 Expression in the Bovine Corpus Luteum: Implications for Luteolysis

2001 • 46 citations

Real-Time Relationships in Intraluteal Release among Prostaglandin F2α, Endothelin-1, and Angiotensin II During Spontaneous Luteolysis in the Cow1

2004 • 44 citations

Effect of Intraluteal Injection of Endothelin Type A Receptor Antagonist on PGF2.ALPHA.-induced Luteolysis in the Cow

2006 • 43 citations

Characterization and Regulation of Type A Endothelin Receptor Gene Expression in Bovine Luteal Cell Types

1999 • 43 citations

Endothelin-1 Activates MAP Kinases and c-Jun in Pulmonary Artery Smooth Muscle

1998 • 38 citations

Endothelin-1 receptors and biosynthesis in the corpus luteum: Molecular and physiological implications

2002 • 38 citations

Involvement of extracellular Ca2+ influx through voltage-independent Ca2+ channels in endothelin-1 function

2005 • 37 citations

High levels of immunoreactive endothelin-1 in human follicular fluids

1993 • 37 citations

Expression of endothelin-1 gene and protein in human granulosa cells.

1996 • 37 citations

Rat Ovarian Granulosa Cell as a Site of Endothelin Reception and Action: Attenuation of Gonadotropin-Stimulated Steroidogenesis via Perturbation of the A-Kinase Signaling Pathway1

1994 • 34 citations

Gβγ-mediated Prostacyclin Production and cAMP-dependent Protein Kinase Activation by Endothelin-1 Promotes Vascular Smooth Muscle Cell Hypertrophy through Inhibition of Glycogen Synthase Kinase-3

2007 • 32 citations

Identification, Characterization, and Biological Activity of Endothelin Receptors in Human Ovary¹

1997 • 31 citations

Gene Expression of Endothelin-1 in the Porcine Ovary: Follicular Development1

2000 • 29 citations

Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane

1993 • 29 citations

Cellular Mechanism of Endothelin-Induced Nitric Oxide Synthesis by Cultured Bovine Endothelial Cells

1993 • 28 citations

Endothelin-1 is an autocrine/paracrine regulator of porcine granulosa cells

1993 • 28 citations

Endothelin-converting Enzyme-1, Abundance of Isoforms a-d and Identification of a Novel Alternatively Spliced Variant Lacking a Transmembrane Domain

2005 • 27 citations

Hormonal Regulation and Cell-Specific Expression of Endothelin-Converting Enzyme 1 Isoforms in Bovine Ovarian Endothelial and Steroidogenic Cells1

2003 • 27 citations

Prostaglandin F2α (PGF2α) independent and dependent regulation of the bovine luteal endothelin system

2004 • 24 citations

Involvement of endothelin‐1 and its receptors in PGF_2α‐induced luteolysis in the rat

2002 • 24 citations

Endothelin-Converting Enzyme-1 Is Expressed on Human Ovarian Follicles and Corpora Lutea of Menstrual Cycle and Early Pregnancy¹

1998 • 24 citations

Endothelin‐1: Expression and Role in Human Corpus Luteum

1998 • 23 citations

Nature of endothelin binding in the porcine ovary.

1995 • 22 citations

The neural crest stem cells: control of neural crest cell fate and plasticity by endothelin-3

2001 • 22 citations

A cooperative action of endothelin-1 with prostaglandin F2α on luteal function in the cow

2005 • 20 citations

Identification, Characterization, and Biological Activity of Endothelin Receptors in Human Ovary

1997 • 20 citations

Distinct Cellular Localization and Regulation of Endothelin-1 and Endothelin-Converting Enzyme-1 Expression in the Bovine Corpus Luteum: Implications for Luteolysis

2001 • 20 citations

Endothelin-Converting Enzyme-1 Is Expressed on Human Ovarian Follicles and Corpora Lutea of Menstrual Cycle and Early Pregnancy

1998 • 18 citations

Expression of endothelin-1 gene and protein in human granulosa cells

1996 • 18 citations

Characterization and Regulation of Type A Endothelin Receptor Gene Expression in Bovine Luteal Cell Types

1999 • 17 citations

Lysosomal traffic of liganded endothelin B receptor

2003 • 17 citations

Changes in the Messenger RNA Expressions of the Endothelin-1 and Angiotensin Systems in Mature Follicles of the Superovulated Bovine Ovary

2007 • 15 citations

Vasoactive Peptides in the Luteolytic Process Activated by PGF2alpha in Pseudopregnant Rabbits at Different Luteal Stages1

2007 • 15 citations

Correlation between 21 amino acid endothelin, intrafollicular steroids and follicle size in stimulated cycles

1999 • 14 citations

Distinct Expression of Endothelin Receptor Subtypes A and B in Luteinized Human Granulosa Cells

2001 • 12 citations

Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1)

2002 • 10 citations

Nature of endothelin binding in the porcine ovary

1995 • 9 citations

Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain.

2006 • 6 citations