Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

Dendritic cells and the control of immunity

1998 • 14,345 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

1999 • 1,268 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

2000 • 786 citations

Causes and consequences of tumour acidity and implications for treatment

2000 • 746 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

1998 • 576 citations

In Breast Carcinoma Tissue, Immature Dendritic Cells Reside within the Tumor, Whereas Mature Dendritic Cells Are Located in Peritumoral Areas

1999 • 540 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

2004 • 459 citations

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

2004 • 458 citations

Activation of the HIF pathway in cancer

2001 • 403 citations

Lactate: mirror and motor of tumor malignancy

2004 • 401 citations

Macrophage responses to hypoxia: relevance to disease mechanisms

1999 • 391 citations

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

1991 • 349 citations

Multicellular spheroids: a three‐dimensionalin vitroculture system to study tumour biology

1998 • 320 citations

104 candidate genes for the hypoxic tumor phenotype

1999 • 283 citations

Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells

1995 • 282 citations

Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein

1998 • 278 citations

Hypoxia-Induced Gene Expression in Human Macrophages

2003 • 277 citations

Dendritic Cells

1999 • 269 citations

Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells

2000 • 245 citations

Lactate in Solid Malignant Tumors: Potential Basis of a Metabolic Classification in Clinical Oncology

2004 • 234 citations

Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing.

2000 • 233 citations

Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines.

1986 • 216 citations

Prostanoids Play a Major Role in the Primary Tumor-Induced Inhibition of Dendritic Cell Differentiation

2002 • 206 citations

Liquid-Overlay Culture of Cellular Spheroids

1984 • 199 citations

Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: a new approach to cancer immunotherapy.

1990 • 186 citations

Survival and Tumor Localization of Adoptively Transferred Melan-A-Specific T Cells in Melanoma Patients

2003 • 163 citations

Hypoxia-Inducible Factor-1-Independent Regulation of Vascular Endothelial Growth Factor by Hypoxia in Colon Cancer

2004 • 161 citations

pH in human tumour xenografts: effect of intravenous administration of glucose

1993 • 161 citations

Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation.

1996 • 160 citations

Defective Function of Langerhans Cells in Tumor-Bearing Animals Is the Result of Defective Maturation from Hemopoietic Progenitors

1998 • 154 citations

Human renal-cell carcinoma tissue contains dendritic cells

1996 • 152 citations

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

1996 • 151 citations

The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response.

2003 • 150 citations

Tumour Hypoxia: The Picture Has Changed in the 1990s

1994 • 117 citations

Metabolic Imaging in Multicellular Spheroids of Oncogene-transfected Fibroblasts

2000 • 104 citations

IFN-γ and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

2002 • 93 citations

IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells.

2001 • 85 citations

Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours

1999 • 76 citations

Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradation products

2003 • 73 citations

CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

2003 • 60 citations

Hypoxia reduces CD80 expression on monocytes but enhances their LPS-stimulated TNF-α secretion

2003 • 55 citations

Three-dimensional co-culture of human monocytes and macrophages with tumor cells: Analysis of macrophage differentiation and activation

1996 • 52 citations

Presence and Localization of Three Lactic Acid Transporters (MCT1, −2, and −4) in Separated Human Granulocytes, Lymphocytes, and Monocytes

2004 • 51 citations

Regulation of T-cell functions by l-lactate

1987 • 47 citations

A system for obtaining large numbers of cryopreserved human monocytes purified by leukapheresis and Counter-current Centrifugation Elutriation (CCE)

1983 • 44 citations

Dendritic antigen-presenting cells from the peripheral blood of renal-cell-carcinoma patients

1995 • 43 citations

Lactate transport in macrophages.

1993 • 29 citations

Review: Dendritic Cells and Cancer: Progress Toward a New Cellular Therapy

1997 • 26 citations

Regulation of intracellular glutathione levels and lymphocyte functions by lactate

1991 • 23 citations

Human melanoma cells inhibit the earliest differentiation steps of human Langerhans cell precursors but failed to affect the functional maturation of epidermal Langerhans cells

2001 • 23 citations