Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

Dendritic cells as therapeutic vaccines against cancer

2005 • 1,195 citations

Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection

2007 • 1,060 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

2006 • 746 citations

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 • 741 citations

Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting

2007 • 728 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

2007 • 686 citations

Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines

2008 • 550 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

A listing of human tumor antigens recognized by T cells: March 2004 update

2004 • 463 citations

T Regulatory and Primed Uncommitted CD4 T Cells Express CD73, Which Suppresses Effector CD4 T Cells by Converting 5′-Adenosine Monophosphate to Adenosine

2006 • 440 citations

FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis

2007 • 412 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

2008 • 360 citations

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

1999 • 301 citations

Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow

2001 • 269 citations

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients.

2001 • 258 citations

Heparanase: a target for drug discovery in cancer and inflammation

2007 • 214 citations

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

2006 • 213 citations

Superior induction of anti‐tumor CTL immunity by extended peptide vaccines involves prolonged, DC‐focused antigen presentation

2008 • 197 citations

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node

2005 • 180 citations

Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma

2007 • 174 citations

Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer

2009 • 168 citations

Recognition of a New ARTC1 Peptide Ligand Uniquely Expressed in Tumor Cells by Antigen-Specific CD4+ Regulatory T Cells

2005 • 156 citations

Telomerase as a universal tumor-associated antigen for cancer immunotherapy

2002 • 152 citations

B Cells Directly Tolerize CD8+ T Cells

1998 • 142 citations

Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach

2000 • 134 citations

Role of Tumor Endothelium in CD4+CD25+ Regulatory T Cell Infiltration of Human Pancreatic Carcinoma

2007 • 130 citations

Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients

2005 • 122 citations

Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors

2004 • 117 citations

Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors

2004 • 109 citations

Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites

2005 • 104 citations

Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens

2002 • 91 citations

Peptide Recognition by Two HLA-A2/Tax11–19-Specific T Cell Clones in Relationship to Their MHC/Peptide/TCR Crystal Structures

1999 • 90 citations

Intra-tumoural regulatory T cells: A potential new target in cancer immunotherapy

2006 • 69 citations

Control of type 1 diabetes by CD4⁺Foxp3⁺ regulatory T cells: lessons from mouse models and implications for human disease

2009 • 65 citations

Long‐lasting cross‐presentation of tumor antigen in human DC

2009 • 60 citations

The Shaping of a Polyvalent and Highly Individual T-Cell Repertoire in the Bone Marrow of Breast Cancer Patients

2006 • 59 citations

EGFR, HER‐2 and COX‐2 levels in colorectal cancer

2008 • 41 citations

Differences in T‐cell immunity toward tumor‐associated antigens in colorectal cancer and breast cancer patients

2003 • 38 citations

Investigation of the expression of melanoma antigen-encoding genes (MAGE-A1 to -A6) in oral squamous cell carcinomas to determine potential targets for gene-based cancer immunotherapy

2005 • 36 citations

Human CD8 Responses to a Complete Epitope Set from Preproinsulin: Implications for Approaches to Epitope Discovery

2008 • 29 citations

Identification of epidermal growth factor receptor-derived peptides immunogenic for HLA-A2+ cancer patients

2004 • 19 citations

The role of heparanase in gastrointestinal cancer (Review).

2005 • 16 citations

Cited By (0)

Loading...