Thymopoiesis in 4 dimensions

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Random walks in biology

1983 • 2,394 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

2003 • 536 citations

Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1

1999 • 478 citations

FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function

2004 • 462 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Heterogeneity among DN1 Prothymocytes Reveals Multiple Progenitors with Different Capacities to Generate T Cell and Non-T Cell Lineages

2004 • 417 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Negative Chemotaxis in Escherichia coli

1974 • 402 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

Photobleaching-Corrected FRET Efficiency Imaging of Live Cells

2004 • 376 citations

Functions of gelsolin: motility, signaling, apoptosis, cancer

1999 • 373 citations

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

2003 • 362 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Rapid leukocyte integrin activation by chemokines

2002 • 341 citations

Active movement of T cells away from a chemokine

2000 • 293 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

Differential expression of homing-associated adhesion molecules by T cell subsets in man.

1990 • 270 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

2002 • 254 citations

Developing a new paradigm for thymus organogenesis

2004 • 242 citations

Switching Repulsion to Attraction: Changing Responses to Slit During Transition in Mesoderm Migration

2001 • 242 citations

Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

2003 • 229 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Regulation of thymocyte differentiation: pre-TCR signals and β-selection

2002 • 225 citations

Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation

2000 • 222 citations

Chemokines define distinct microenvironments in the developing thymus

2000 • 218 citations

The Importation of Hematogenous Precursors by the Thymus Is a Gated Phenomenon in Normal Adult Mice

2001 • 213 citations

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

2003 • 205 citations

Protein localization in living cells and tissues using FRET and FLIM

2003 • 195 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

CCR7 Directs the Migration of Thymocytes into the Thymic Medulla

2004 • 173 citations

Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation

2000 • 163 citations

Characterization of two-photon excitation fluorescence lifetime imaging microscopy for protein localization

2003 • 160 citations

Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice

2003 • 160 citations

Antigen-dependent and -independent Ca2+ Responses Triggered in T Cells by Dendritic Cells Compared with B Cells

1998 • 151 citations

A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation

2003 • 151 citations

A pertussis toxin‐sensitive process controls thymocyte emigration

1991 • 147 citations

Dynamic Interactions of Macrophages with T Cells during Antigen Presentation

1999 • 146 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Thymic generation and regeneration

2003 • 144 citations

A potential role for CD69 in thymocyte emigration

2002 • 144 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Immature CD4+CD8+ Thymocytes Form a Multifocal Immunological Synapse with Sustained Tyrosine Phosphorylation

2002 • 138 citations

Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries

2002 • 138 citations

Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage

2001 • 135 citations

Inhibition of T Cell Receptor-Coreceptor Interactions by Antagonist Ligands Visualized by Live FRET Imaging of the T-Hybridoma Immunological Synapse

2002 • 132 citations

Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells

2000 • 131 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus

1997 • 116 citations

Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation

2002 • 111 citations

Boundary formation in the hindbrain: Eph only it were simple…

2002 • 111 citations

Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment

1998 • 107 citations

Thymocyte emigration is mediated by active movement away from stroma-derived factors

2002 • 104 citations

The Generation of Mature, Single-Positive Thymocytes In Vivo Is Dysregulated by CD69 Blockade or Overexpression

2002 • 104 citations

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

2001 • 98 citations

RHAMM, a Receptor for Hyaluronan-Mediated Motility, on Normal Human Lymphocytes, Thymocytes and Malignant B Cells: a Mediator in B cell Malignancy?

1994 • 96 citations

L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor

2004 • 93 citations

Stromal Cells Provide the Matrix for Migration of Early Lymphoid Progenitors Through the Thymic Cortex

2002 • 91 citations

A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?

2003 • 89 citations

Real-time imaging of lymphocytes in vivo

2003 • 88 citations

Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice

1999 • 84 citations

On the brink of becoming a T cell

2002 • 84 citations

Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines

2000 • 81 citations

Regulation of directed motility in Myxococcus xanthus

1997 • 77 citations

The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate

1993 • 75 citations

Early stages in human and mouse T-cell development

1994 • 63 citations

Molecular interactions at the T cell–antigen-presenting cell interface

2003 • 63 citations

Cell migration and the anatomic control of thymocyte precursor differentiation

2000 • 59 citations

Expression and Function of the Eph A Receptors and Their Ligands Ephrins A in the Rat Thymus

2002 • 57 citations

Gated Importation of Prothymocytes by Adult Mouse Thymus Is Coordinated with Their Periodic Mobilization from Bone Marrow

2003 • 56 citations

Actin structural proteins in cell motility

1992 • 55 citations

Cells on the Move: A Dialogue Between Polarization and Motility

2000 • 44 citations

Negative chemotaxis in cellular slime molds

1977 • 44 citations

Measurement of chemotaxis of polymorphonuclear leukocytes in vitro

1988 • 41 citations

Functional activity of CD44 isoforms in haemopoiesis of the rat

1997 • 37 citations

Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated

1995 • 37 citations

Major T Cell Progenitor Activity in Bone Marrow–derived Spleen Colonies

2002 • 34 citations

Cytoskeletal changes associated with cell motility.

1993 • 32 citations

Characterization of Vascular Adhesion Molecules that may Facilitate Progenitor Homing in the Post‐natal Mouse Thymus

2003 • 31 citations

Two-Photon imaging in Intact Lymphoid Tissue

2002 • 28 citations

Thymic stromal cells and positive selection

2001 • 26 citations

Visualizing thymocyte motility using 2‐photon microscopy

2003 • 21 citations

Function of CD44(Pgp-1) homing receptor in human T cell precursors

1989 • 21 citations

Haemopoietic progenitor cell differentiation: flow cytometric assessment in bone marrow and thymus

1995 • 20 citations

Cell death in the thymus—it's all a matter of contacts

2003 • 20 citations

Compartmentalized Eph receptor and ephrin expression in the thymus

2002 • 19 citations

Real-time imaging of T-cell development

2004 • 11 citations

Beta₁‐Integrins Control Spontaneous Adhesion and Motility of Human Progenitor Thymocytes and Regulate Differentiation‐Dependent Expression of the Receptor for Hyaluronan‐Mediated Motility

1999 • 11 citations