The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein

1999 • 844 citations

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

1998 • 708 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility

2003 • 496 citations

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

2003 • 448 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

On the Dynamics of TCR:CD3 Complex Cell Surface Expression and Downmodulation

2000 • 364 citations

Synaptic pattern formation during cellular recognition

2001 • 346 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

Negative receptor signalling

2003 • 333 citations

Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation

1997 • 316 citations

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2002 • 184 citations

From synapses to immunological memory: the role of sustained T cell stimulation

2000 • 153 citations

Positive and negative regulation of t-cell activation by adaptor proteins

2001 • 137 citations

Serial TCR Engagement and Down-Modulation by Peptide:MHC Molecule Ligands: Relationship to the Quality of Individual TCR Signaling Events

1999 • 117 citations

Activated TCRs remain marked for internalization after dissociation from pMHC

2002 • 116 citations

Cooperative enhancement of specificity in a lattice of T cell receptors

2001 • 67 citations

The Proliferative Capacity of Individual Naive CD4+T Cells Is Amplified by Prolonged T Cell Antigen Receptor Triggering

2002 • 59 citations

Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation

1998 • 24 citations