Molecular interactions at the T cell–antigen-presenting cell interface

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

The Immunological Synapse

2001 • 987 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Direct observation of ligand recognition by T cells

2002 • 802 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

2003 • 599 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

2003 • 480 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

2003 • 448 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Functional antigen-independent synapses formed between T cells and dendritic cells

2001 • 287 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

2001 • 231 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes

2001 • 213 citations

T Cell Receptor and Coreceptor CD8αα Bind Peptide-MHC Independently and with Distinct Kinetics

1999 • 194 citations

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

2000 • 178 citations

CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

2002 • 142 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Multivalent structure of an αβT cell receptor

1999 • 140 citations

Immature CD4+CD8+ Thymocytes Form a Multifocal Immunological Synapse with Sustained Tyrosine Phosphorylation

2002 • 138 citations

Inhibition of T Cell Receptor-Coreceptor Interactions by Antagonist Ligands Visualized by Live FRET Imaging of the T-Hybridoma Immunological Synapse

2002 • 132 citations

Interaction of T cells with APCs: the serial encounter model

2001 • 129 citations

Cross-Antagonism of a T Cell Clone Expressing Two Distinct T Cell Receptors

1999 • 108 citations

Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling

2003 • 108 citations

T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation.

1989 • 103 citations

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4

2001 • 103 citations

Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies.

1989 • 103 citations

The diversity of immunological synapses

2003 • 92 citations

A Correlation between TCR Vα Docking on MHC and CD8 Dependence

2003 • 92 citations

Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes.

1988 • 89 citations

T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs

1999 • 73 citations

Mechanism of Lck Recruitment to the T‐Cell Receptor Cluster as Studied by Single‐Molecule‐Fluorescence Video Imaging

2003 • 64 citations

Cutting Edge: Dueling TCRs: Peptide Antagonism of CD4+ T Cells with Dual Antigen Specificities

1999 • 51 citations

Cutting Edge: A Test of the Dominant Negative Signal Model for TCR Antagonism

1999 • 46 citations

Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck

1998 • 39 citations

Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells

2003 • 28 citations