Cells on the Move: A Dialogue Between Polarization and Motility

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Functional rafts in cell membranes

1997 • 9,471 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

The locomotion of fibroblasts in culture

1971 • 955 citations

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors.

1977 • 905 citations

Lymphotactin: a Cytokine that Represents a New Class of Chemokine

1994 • 668 citations

G Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells

1998 • 626 citations

Molecular interactions in cell adhesion complexes

1997 • 583 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Polarized sorting in epithelia

1990 • 544 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Molecular insights into cancer invasion: strategies for prevention and intervention.

1995 • 500 citations

Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

1999 • 450 citations

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

1999 • 444 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

1998 • 440 citations

Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture

1990 • 425 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains

1999 • 345 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Fibronectin and integrins in invasion and metastasis

1995 • 315 citations

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.

1994 • 276 citations

Receptors induce chemotaxis by releasing the βγ subunit of G _i , not by activating G _q or G _s

1997 • 276 citations

Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis.

1981 • 263 citations

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility

1999 • 254 citations

Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.

1996 • 243 citations

Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells.

1996 • 238 citations

Dynamic Distribution of Chemoattractant Receptors in Living Cells During Chemotaxis and Persistent Stimulation

1997 • 234 citations

Dynamics of a Chemoattractant Receptor in Living Neutrophils during Chemotaxis

1999 • 230 citations

The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells

1996 • 223 citations

Chemokines induce migrational responses in human breast carcinoma cell lines

1997 • 222 citations

Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts.

1992 • 222 citations

Neuronal polarity: Essential role of protein–lipid complexes in axonal sorting

1998 • 222 citations

Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis

1997 • 219 citations

Mechanisms of sensing chemical gradients by polymorphonuclear leukocytes

1974 • 198 citations

The inner world of cell adhesion: integrin cytoplasmic domains

1994 • 193 citations

Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells.

1996 • 171 citations

Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of G_αi-coupled receptors

1997 • 158 citations

The Transcription Factor AP-1 Is Required for EGF-induced Activation of Rho-like GTPases, Cytoskeletal Rearrangements, Motility, and In Vitro Invasion of A431 Cells

1998 • 154 citations

The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells

1989 • 151 citations

Local and spatially coordinated movements in Dictyostelium discoideum amoebae during chemotaxis

1982 • 143 citations

Gαi Is Not Required for Chemotaxis Mediated by Gi-coupled Receptors

1999 • 141 citations

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors.

1986 • 136 citations

Maturation of the axonal plasma membrane requires upregulation of sphingomyelin synthesis and formation of protein-lipid complexes

1999 • 128 citations

Localization of Autocrine Motility Factor Receptor to Caveolae and Clathrin-independent Internalization of Its Ligand to Smooth Endoplasmic Reticulum

1998 • 119 citations

Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis

1999 • 117 citations

In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals

1995 • 111 citations

Rapid cellular translocation is related to close contacts formed between various cultured cells and their substrata

1982 • 103 citations

Protein factors which regulate cell motility

1989 • 100 citations

Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone

1997 • 76 citations

A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation

1999 • 73 citations

Cellular memory: Neutrophil orientation reverses during temporally decreasing chemoattractant concentrations

1998 • 67 citations

Tyrosine Phosphatase SHP-2 Is Involved in Regulation of Platelet-derived Growth Factor-induced Migration

1999 • 64 citations

Antibody mapping of functional domains in vinculin.

1990 • 64 citations

Oncostatin M induces basic fibroblast growth factor expression in endothelial cells and promotes endothelial cell proliferation, migration and spindle morphology

1997 • 59 citations

Studies of chemotactic factor-induced polarity in human neutrophils : Lipid mobility, receptor distribution and the time-sequence of polarization

1991 • 53 citations

Rapid growth cone translocation on laminin is supported by lamellipodial not filopodial structures

1989 • 40 citations

Replacement of Tyrosine 1251 in the Carboxyl Terminus of the Insulin-like Growth Factor-I Receptor Disrupts the Actin Cytoskeleton and Inhibits Proliferation and Anchorage-independent Growth

1998 • 37 citations

Human fibroblasts express functional IL-2 receptors formed by the IL-2R alpha- and beta-chain subunits: association of IL-2 binding with secretion of the monocyte chemoattractant protein-1.

1996 • 33 citations

Signaling Through CD43 Induces Natural Killer Cell Activation, Chemokine Release, and PYK-2 Activation

1999 • 30 citations

Localization of chemotactic peptide receptors on rabbit neutrophils

1984 • 15 citations

Fluorescent chemotactic peptides as tools to identify the f-Met-Leu-Phe receptor on human granulocytes

1990 • 12 citations