Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Epidemiologic evidence for multiple sclerosis as an infection

1993 • 467 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Primary demyelination in Theiler's virus infection. An ultrastructural study.

1975 • 273 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.

1994 • 236 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells.

1979 • 207 citations

Relapsing experimental allergic encephalomyelitis in the SJL/J mouse.

1981 • 197 citations

Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system.

1990 • 173 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

1988 • 154 citations

Interferon-γ and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions

1988 • 142 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice.

1992 • 134 citations

Acute experimental allergic encephalomyelitis in the mouse: Immunopathology of the developing lesion

1985 • 134 citations

Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein.

1983 • 130 citations

Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis

1990 • 115 citations

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.

1993 • 111 citations

Development of Reactivity to New Myelin Antigens during Chronic Relapsing Autoimmune Demyelination

1993 • 98 citations

Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.

1988 • 92 citations

T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis

1991 • 85 citations

Myelin proteolipid protein induces demyelinating disease in mice

1987 • 83 citations

Ia expression in chronic relapsing experimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice.

1986 • 78 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction.

1990 • 77 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1994 • 75 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition.

1992 • 66 citations

Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid

1990 • 56 citations

The adoptive transfer of chronic relapsing experimental allergic encephalomyelitis with lymph node cells sensitized to myelin proteolipid protein

1989 • 55 citations

Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance.

1991 • 53 citations

Kinetics and specificity of T and B cell responses in relapsing experimental allergic encephalomyelitis.

1987 • 46 citations

Preparation of Proteolipids

1978 • 43 citations

Antigen-Specific Tolerance as a Therapy for Experimental Autoimmune Encephalomyelitis

1992 • 43 citations

Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. T cell receptor peptide regulation of T cell clones expressing cross-reactive V beta genes.

1992 • 42 citations

Epidemiologic evidence for multiple sclerosis as an infection.

1993 • 34 citations

MYELIN PROTEOLIPID PROTEIN

1988 • 24 citations

Monoclonal antibody-induced inhibition of relapsing EAE in SJL/J mice correlates with inhibition of neuroantigen-specific cell-mediated immune responses☆

1987 • 20 citations

Epitope and functional specificity of peripheral tolerance induction in experimental autoimmune encephalomyelitis in adult Lewis rats.

1994 • 17 citations

Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides.

1994 • 17 citations