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Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells

Data up to Jan 2025

Published2004
Citations38
References35

Total Citations Per Year

Abstract

References (35)

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Disease modifying therapies in multiple sclerosis: Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines: Table 1.

2002 • 812 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

McAlpine's Multiple Sclerosis

2006 • 768 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

2000 • 412 citations

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

1999 • 326 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

1998 • 288 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

1994 • 243 citations

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1994 • 237 citations

Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1

2000 • 222 citations

Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex

2000 • 192 citations

Copolymer 1 acts against the immunodominant epitope 82–100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking

1999 • 191 citations

Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial

1996 • 176 citations

Mechanisms of immunomodulation by glatiramer acetate

2000 • 161 citations

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

1988 • 115 citations

Promiscuous Binding of Synthetic Copolymer 1 to Purified HLA-DR Molecules

1998 • 111 citations

Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease

1997 • 104 citations

A phase I trial of solubilized DR2:MBP 84-102 (AG284) in multiple sclerosis

2000 • 65 citations

Binding Motifs of Copolymer 1 to Multiple Sclerosis- and Rheumatoid Arthritis-Associated HLA-DR Molecules

1999 • 57 citations

Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

2004 • 48 citations

Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis.

1994 • 46 citations

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

2002 • 34 citations

HLA, molecular mimicry and multiple sclerosis.

2000 • 31 citations

Identification of Autoimmune T Cells Among In Vivo Expanded CD25+ T Cells in Multiple Sclerosis

1999 • 27 citations

In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis

2003 • 25 citations

Kinetic profiles of cerebrospinal fluid anti-MBP in response to intravenous MBP synthetic peptide DENP85VVHFFKNIVTP96RT in multiple sclerosis patients

2000 • 24 citations

Genetic Aspects of Multiple Sclerosis

1999 • 17 citations

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Modified amino acid copolymers suppress myelin basic protein 85–99-induced… (2004) – Proceedings of the National Academy of Sciences | Metascience Observatory Explorer