Therapeutic potential of oral tolerance

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Report of the task group on reference man

1979 • 1,754 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Anatomical basis of tolerance and immunity to intestinal antigens

2003 • 1,365 citations

NODs: intracellular proteins involved in inflammation and apoptosis

2003 • 1,041 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Local control of the immune response in the liver

2000 • 593 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Role of Toll-Like Receptors in Pathogen Recognition

2003 • 545 citations

Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing Agent

1946 • 510 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Induction of immunological paralysis in two zones of dosage

1964 • 439 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node

2002 • 387 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.

1994 • 318 citations

Oral desensitizing treatment in food allergy: clinical and immunological results

2003 • 304 citations

T cell anergy and costimulation

2003 • 299 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Mucosal Administration of Heat Shock Protein-65 Decreases Atherosclerosis and Inflammation in Aortic Arch of Low-Density Lipoprotein Receptor-Deficient Mice

2002 • 268 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen.

1981 • 255 citations

Antacid medication inhibits digestion of dietary proteins and causes food allergy A fish allergy model in balb/c mice

2003 • 242 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

Suppressor T Cells for IgE and IgG in Peyer's Patches of Mice Made Tolerant by the Oral Administration of Ovalbumin

1978 • 238 citations

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

1997 • 231 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

Immune Responses to Fed Protein Antigens in Mice. 3. Systemic Tolerance or Priming Is Related to Age at Which Antigen Is First Encountered

1984 • 221 citations

Treatment of rheumatoid arthritis with oral type II collagen: Results of a multicenter, double-blind, placebo-controlled trial

1998 • 219 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1998 • 218 citations

ANTERIOR CHAMBER ASSOCIATED IMMUNE DEVIATION (ACAID): REGULATION, BIOLOGICAL RELEVANCE, AND IMPLICATIONS FOR THERAPY

2002 • 210 citations

Copolymer 1 acts against the immunodominant epitope 82–100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking

1999 • 191 citations

Oral tolerance with heat shock protein 65 attenuates mycobacterium tuberculosis-inducedand high-fat-diet-driven atherosclerotic lesions

2002 • 186 citations

Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches

2002 • 181 citations

Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells

2003 • 177 citations

Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation

2003 • 166 citations

Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells

2002 • 165 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein

1990 • 164 citations

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease☆

2004 • 159 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked Trial

1997 • 155 citations

Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia

1997 • 153 citations

CD4⁺ but not CD8⁺T cells are required for the induction of oral tolerance

1995 • 153 citations

A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation

2003 • 153 citations

Oral Tolerance to Myelin Basic Protein Induces Regulatory TGF-β-Secreting T Cells in Peyer's Patches of SJL Mice

1994 • 151 citations

Suppression of Asthma-like Responses in Different Mouse Strains by Oral Tolerance

2001 • 150 citations

Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches

2001 • 145 citations

Oral Tolerance in Experimental Autoimmune Encephalomyelitis

1996 • 136 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-β/interleukin-10 and suppression of experimental autoimmune encephalomyelitis

2003 • 120 citations

IL-4 and IL-10 Are Both Required for the Induction of Oral Tolerance

1999 • 118 citations

Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals

1994 • 114 citations

Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1

1999 • 106 citations

Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model

1999 • 102 citations

United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates

2001 • 98 citations

CTLA-4 is required for the induction of high dose oral tolerance

1998 • 97 citations

Control of rheumatoid arthritis by oral tolerance

2001 • 93 citations

The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding

1989 • 90 citations

TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia.

1997 • 90 citations

CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms

2002 • 90 citations

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.

1999 • 89 citations

Prevention of mucosally induced uveitis with a HSP60‐derived peptide linked to cholera toxin B subunit

2003 • 87 citations

Systemic antigen in the treatment of T-cell-mediated autoimmune diseases

1997 • 85 citations

Oral Administration of Myelin Induces Antigen‐specific TGF‐β1 Secreting T Cells in Patients with Multiple Sclerosis^a

1997 • 80 citations

United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates

2001 • 79 citations

Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells

2003 • 78 citations

Insulin in Oral Immune “Tolerance”: A One-Amino Acid Change in the B Chain Makes the Difference

1999 • 78 citations

Effect of in Vivo Depletion of CD4+ and CD8+ Cells on the Induction and Maintenance of Oral Tolerance

1995 • 74 citations

Visualization of peptide presentation following oral application of antigen in normal and Peyer's patches‐deficient mice

2003 • 73 citations

Oral tolerance with an HLA-peptide mimicking retinal autoantigen as a treatment of autoimmune uveitis

1999 • 65 citations

Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8+ T Cells in the Normal Gut Mucosa

1998 • 63 citations

Molecular mimicry as a therapeutic approach for an autoimmune disease: oral treatment of uveitis-patients with an MHC-peptide crossreactive with autoantigen—first results

1997 • 62 citations

Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-β expression and prevents allergy in adult life

2003 • 61 citations

THE EFFECT OF ORAL IMMUNIZATION ON CORNEAL ALLOGRAFT SURVIVAL1

1996 • 59 citations

Oral Administration of Insulin to Neonates Suppresses Spontaneous and Cyclophosphamide Induced Diabetes in the NOD Mouse

2001 • 59 citations

Modulation of intestinal and systemic immune responses to a fed protein antigen, in mice.

1986 • 57 citations

Mucosal Tolerance in a Murine Model of Experimental Autoimmune Encephalomyelitisa

1996 • 55 citations

Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen

2000 • 55 citations

Induction of oral tolerance in TGF-beta 1 null mice.

1998 • 54 citations

The role of antigen recognition and suppressor cells in mice with oral tolerance to ovalbumin.

1985 • 53 citations

Abrogation of Oral Tolerance by Feeding Encapsulated Antigen

2000 • 52 citations

Oral administration of an immunodominant T-cell epitope downregulates Th1/Th2 cytokines and prevents experimental myasthenia gravis

1999 • 52 citations

The Oral Administration of Low-Dose Antigen Induces Activation Followed by Tolerization, While High-Dose Antigen Induces Tolerance without Activation

1997 • 51 citations

Inhibition of relapsing experimental autoimmune encephalomyelitis in SJL mice by feeding the immunodominant PLP139-151 peptide

1996 • 48 citations

Induction of oral tolerance in splenocyte recipients toward pretransplant antigens ameliorates chronic graft versus host disease in a murine model

2000 • 47 citations

Gender differences in protection from EAE induced by oral tolerance with a peptide analogue of MBP-Ac1-11

1999 • 46 citations

Inhibition of Experimental Autoimmune Uveoretinitis by Oral Administration of S-Antigen and Synthetic Peptides

1992 • 46 citations

Induction of Oral Tolerance in TGF-β1 Null Mice

1998 • 45 citations

Oral tolerization ameliorates liver disorders associated with chronic graft versus host disease in mice

2000 • 44 citations

Divergent effects of bacterial lipopolysaccharide on immunity to orally administered protein and particulate antigens in mice.

1986 • 43 citations

Successful Allogeneic Bone Marrow Transplantation (BMT) by Injection of Bone Marrow Cells via Portal Vein: Stromal Cells as BMT-Facilitating Cells

2001 • 42 citations

Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes

2003 • 41 citations

Mucosal Tolerance to Experimental Autoimmune Myasthenia Gravis Is Associated with Down‐regulation of AChR‐specific IFN‐γ‐expressing Th1‐like Cells and Up‐regulation of TGF‐β mRNA in Mononuclear Cells

1996 • 40 citations

Splenectomy abrogates the induction of oral tolerance in experimental autoimmune uveoretinitis

1993 • 40 citations

Therapeutic Manipulation of the Immune System: Enhancement of Innate and Adaptive Mucosal Immunity

2003 • 38 citations

Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-gamma signaling pathway.

1999 • 38 citations

Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination

2000 • 38 citations

Oral immunisation as a strategy for enhancing corneal allograft survival

1997 • 37 citations

The Cholera Toxin B Subunit is a Mucosal Adjuvant for Oral Tolerance Induction in Type 1 Diabetes

2003 • 35 citations

The β2-Adrenergic Agonist Salbutamol Potentiates Oral Induction of Tolerance, Suppressing Adjuvant Arthritis and Antigen-Specific Immunity

2002 • 34 citations

Future therapeutic options in food allergy

2003 • 33 citations

Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines

2002 • 32 citations

Respiratory Tolerance in the Protection Against Asthma

2003 • 31 citations

Active suppression in orally tolerized rats coincides within situtransforming growth factor-beta (TGF-β) expression in the draining lymph nodes

1999 • 30 citations

Normal Induction of Oral Tolerance in the Absence of a Functional IL-12-Dependent IFN-γ Signaling Pathway

1999 • 30 citations

INDUCTION OF DONOR-SPECIFIC HYPORESPONSIVENESS AND PROLONGATION OF CARDIAC ALLOGRAFT SURVIVAL BY JEJUNAL ADMINISTRATION OF DONOR SPLENOCYTES

1999 • 29 citations

CD8 T-Cells Are Not Essential for the Induction of “Low-Dose” Oral Tolerance

1996 • 29 citations

Murine Model of Oral Tolerance: Induction of Fas‐Mediated Apoptosis by Blockade of Interleukin‐12

1998 • 27 citations

Phenotypic analysis of oral tolerance to alloantigens: evidence that the indirect pathway of antigen presentation is involved1

2002 • 26 citations

Decrease in Systemic Tolerance to Fed Ovalbumin in Indomethacin-Treated Mice

1996 • 26 citations

Gastric administration of recombinant 65 kDa heat shock protein delays the severity of type II collagen induced arthritis in mice.

1998 • 23 citations

A ROLE FOR PERSISTING ANTIGEN, ANTIGEN PRESENTATION, AND ICAM-1 IN INCREASED RENAL GRAFT SURVIVAL AFTER ORAL OR PORTAL VEIN DONOR-SPECIFIC IMMUNIZATION1

1998 • 22 citations

Selective emigration of suppressor T cells from Peyer's patches

1984 • 21 citations

MODULATION OF IMMUNE RESPONSES AFTER PORTAL VENOUS INJECTION OF ANTIGEN1

2001 • 20 citations

Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen

2001 • 19 citations

A NOVEL STRATEGY FOR ORGAN ALLOGRAFTS USING SUBLETHAL (7 Gy) IRRADIATION FOLLOWED BY INJECTION OF DONOR BONE MARROW CELLS VIA PORTAL VEIN1

2001 • 17 citations

Requirement for splenic CD4+ T cells in the immune privilege of the anterior chamber of the eye

1999 • 15 citations

Oral Tolerance Induction inDermatophagoides pteronyssinus-Sensitized Mice Induces Inhibition of IgE Response and Upregulation of TGF-βSecretion

2001 • 15 citations

A blood‐borne antigen induces rapid T–B cell contact: a potential mechanism for tolerance induction

2002 • 14 citations

Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function

2003 • 13 citations

The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid

2002 • 10 citations

Immunogenicity of recombinant type IX collagen in murine collagen‐induced arthritis

2002 • 9 citations

Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common ??-chain-dependent cytokine signals1

2002 • 9 citations

Nasal instillation of gpMBP can exacerbate murine EAE: effect of mucosal priming is an age-dependent phenomenon

2003 • 6 citations

Induction of specific transplantation immunity by oral immunization with allogeneic cells

2000 • 6 citations

Induction of tolerance by oral administration of a tolerogenic allochimeric donor/recipient class I MHC protein

1999 • 5 citations

Differences Between Two Strains of Myelin Basic Protein (MBP) TCR Transgenic Mice: Implications for Tolerance Induction

2002 • 5 citations