Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.

1990 • 454 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8⁺T cells in autoimmune diabetes

2003 • 378 citations

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice

1996 • 266 citations

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice

2001 • 213 citations

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

2003 • 201 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide–MHC class II chimera

2002 • 113 citations

Mechanism Underlying Counterregulation of Autoimmune Diabetes by IL-4

1997 • 100 citations

Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen

1994 • 99 citations

Regulatory Th2-type T cell Lines Against Insulin and GAD Peptides Derived from Orally- and Nasally-Treated NOD Mice Suppress Diabetes

1999 • 94 citations

Peptide-MHC Class II Dimers as Therapeutics to Modulate Antigen-Specific T Cell Responses in Autoimmune Diabetes

2003 • 81 citations

Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens

1997 • 81 citations

Treatment of NOD Diabetes with a Novel Peptide of the hsp60 Molecule Induces Th2-type Antibodies

1997 • 68 citations

Detection of Early Changes in Autoimmune T Cell Phenotype and Function Following Intravenous Administration of Type II Collagen in a TCR-Transgenic Model

2002 • 38 citations

Induction of autoimmune encephalomyelitis and uveitis in B6 and (B6×SJL) mice by peptides derived from myelin/oligodendrocyte glycoprotein

2002 • 24 citations

Proinsulin 2 Knockout NOD Mice

2002 • 20 citations

Differences Between Two Strains of Myelin Basic Protein (MBP) TCR Transgenic Mice: Implications for Tolerance Induction

2002 • 5 citations