Back to search

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

Data up to Jan 2025

Published2005
Citations35
References43

Total Citations Per Year

Abstract

References (43)

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability

1998 • 504 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1971 • 431 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

1999 • 326 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

1998 • 288 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.

1994 • 216 citations

Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex

2000 • 192 citations

Myelin proteolipid protein-specific CD4+CD25+regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

2004 • 186 citations

Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions

1997 • 169 citations

Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides.

1994 • 157 citations

T-cell recognition of myelin basic protein

1991 • 134 citations

Suppression of experimental allergic encephalomyelitis in rhesus monkeys by a synthetic basic copolymer

1974 • 127 citations

Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen

1973 • 123 citations

T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.

1995 • 121 citations

THE GENETICS OF SUSCEPTIBILITY TO MULTIPLE SCLEROSIS1

1982 • 112 citations

Promiscuous Binding of Synthetic Copolymer 1 to Purified HLA-DR Molecules

1998 • 111 citations

T suppressor hybridomas and interleukin‐2‐dependent lines induced by copolymer 1 or by spinal cord homogenate down‐regulate experimental allergic encephalomyelitis

1993 • 88 citations

Detection of Autoreactive Myelin Proteolipid Protein 139–151-Specific T Cells by Using MHC II (IAs) Tetramers

2003 • 70 citations

A phase I trial of solubilized DR2:MBP 84-102 (AG284) in multiple sclerosis

2000 • 65 citations

Genetic Factors in Multiple Sclerosis

1993 • 64 citations

Binding Motifs of Copolymer 1 to Multiple Sclerosis- and Rheumatoid Arthritis-Associated HLA-DR Molecules

1999 • 57 citations

Th1 and Th2 cells in autoimmunity

1995 • 52 citations

The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families

1994 • 49 citations

Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

2004 • 48 citations

Induction of Experimental Allergic Encephalomyelitis by Myelin Proteolipid-Protein-Specific T Cell Clones and Synthetic Peptides

1991 • 47 citations

IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis

2003 • 44 citations

Regulation of Experimental Autoimmune Encephalomyelitis by Interleukin‐12

1996 • 40 citations

Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells

2004 • 38 citations

Role of Th1 and Th2 cells in autoimmune demyelinating disease

1998 • 38 citations

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

2002 • 34 citations

Identification of Autoimmune T Cells Among In Vivo Expanded CD25+ T Cells in Multiple Sclerosis

1999 • 27 citations

Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses

2001 • 20 citations

Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs

2001 • 15 citations

Cited By (0)

No citing papers found in database

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in… (2005) – Proceedings of the National Academy of Sciences | Metascience Observatory Explorer