Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis
Data up to Jan 2025
Total Citations Per Year
Abstract
References (43)
Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis
1995 • 1,903 citations
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
2000 • 805 citations
IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice
1998 • 558 citations
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
2000 • 506 citations
Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability
1998 • 504 citations
A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis
1987 • 465 citations
T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis
1990 • 447 citations
Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide
1971 • 431 citations
An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
1995 • 422 citations
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
1996 • 389 citations
Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.
1989 • 372 citations
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
1999 • 326 citations
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.
1994 • 323 citations
Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein
1998 • 288 citations
Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy
1992 • 251 citations
Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.
1994 • 216 citations
Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex
2000 • 192 citations
Myelin proteolipid protein-specific CD4+CD25+regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis
2004 • 186 citations
Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions
1997 • 169 citations
Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides.
1994 • 157 citations
T-cell recognition of myelin basic protein
1991 • 134 citations
Suppression of experimental allergic encephalomyelitis in rhesus monkeys by a synthetic basic copolymer
1974 • 127 citations
Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen
1973 • 123 citations
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.
1995 • 121 citations
THE GENETICS OF SUSCEPTIBILITY TO MULTIPLE SCLEROSIS1
1982 • 112 citations
Promiscuous Binding of Synthetic Copolymer 1 to Purified HLA-DR Molecules
1998 • 111 citations
T suppressor hybridomas and interleukin‐2‐dependent lines induced by copolymer 1 or by spinal cord homogenate down‐regulate experimental allergic encephalomyelitis
1993 • 88 citations
Detection of Autoreactive Myelin Proteolipid Protein 139–151-Specific T Cells by Using MHC II (IAs) Tetramers
2003 • 70 citations
A phase I trial of solubilized DR2:MBP 84-102 (AG284) in multiple sclerosis
2000 • 65 citations
Genetic Factors in Multiple Sclerosis
1993 • 64 citations
Binding Motifs of Copolymer 1 to Multiple Sclerosis- and Rheumatoid Arthritis-Associated HLA-DR Molecules
1999 • 57 citations
Th1 and Th2 cells in autoimmunity
1995 • 52 citations
The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families
1994 • 49 citations
Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms
2004 • 48 citations
Induction of Experimental Allergic Encephalomyelitis by Myelin Proteolipid-Protein-Specific T Cell Clones and Synthetic Peptides
1991 • 47 citations
IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis
2003 • 44 citations
Regulation of Experimental Autoimmune Encephalomyelitis by Interleukin‐12
1996 • 40 citations
Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells
2004 • 38 citations
Role of Th1 and Th2 cells in autoimmune demyelinating disease
1998 • 38 citations
Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis
2002 • 34 citations
Identification of Autoimmune T Cells Among In Vivo Expanded CD25+ T Cells in Multiple Sclerosis
1999 • 27 citations
Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses
2001 • 20 citations
Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs
2001 • 15 citations
Cited By (0)
No citing papers found in database