Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-β mRNA

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.

1993 • 317 citations

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1993 • 280 citations

[29] Production and assay of antibodies to acetylcholine receptors

1981 • 277 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

1996 • 244 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Interleukin‐12 induces interferon‐γ‐dependent switching of IgG alloantibody subclass

1996 • 160 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant

1995 • 142 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein.

1996 • 111 citations

Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls.

1991 • 108 citations

Split tolerance of T_hl and T_h2 cells in tolerance to Theiler's murine encephalomyelitis virus

1993 • 107 citations

Suppression of experimental autoimmune myasthenia gravis by nasal administration of acetylcholine receptor

1995 • 96 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.

1993 • 87 citations

Anergy in vivo: down-regulation of antigen-specific CD4⁺ T_h1 but not T_h2 cytokine responses

1994 • 79 citations

A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats.

1995 • 70 citations

Treatment of Autoimmune Disease by Oral Tolerance to Autoantigens

1996 • 65 citations

Intranasal administration of retinal antigens suppresses retinal antigen-induced experimental autoimmune uveoretinitis.

1994 • 60 citations

Mucosal Tolerance in a Murine Model of Experimental Autoimmune Encephalomyelitisa

1996 • 55 citations

Mucosal Tolerance to Experimental Autoimmune Myasthenia Gravis Is Associated with Down‐regulation of AChR‐specific IFN‐γ‐expressing Th1‐like Cells and Up‐regulation of TGF‐β mRNA in Mononuclear Cells

1996 • 40 citations

Altered Th1/Th2 balance associated with non‐major histocompatibility complex genes in collagen‐induced arthritis in resistant and non‐resistant rat strains

1997 • 34 citations

Shift from anti-to proinflammatory cytokine profiles in microglia through LPS-or IFN-γ-mediated pathways

1996 • 27 citations

Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease.

1994 • 27 citations

Antigen-specific immunotherapy of autoimmune disease: a commentary

1996 • 18 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat, by administration of an acylated synthetic peptide of myelin basic protein

1997 • 16 citations