DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Lipopolysaccharide-Activated B Cells Down-Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice

2001 • 392 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

1996 • 315 citations

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

1993 • 254 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice

2003 • 221 citations

Genetic adjuvants for DNA vaccines

2001 • 182 citations

Treatment of murine lupus with cDNA encoding IFN-γR/Fc

2000 • 162 citations

Understanding autoimmune diabetes: insights from mouse models

2002 • 118 citations

Genes and Cellular Requirements for Autoimmune Diabetes Susceptibility in Nonobese Diabetic Mice

2001 • 117 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

2003 • 115 citations

Oral Administration of the Immunodominant B-chain of Insulin Reduces Diabetes in a Co-transfer Model of Diabetes in the NOD Mouse and is Associated with a Switch from Th1 to Th2 Cytokines

1997 • 109 citations

Low CD86 Expression in the Nonobese Diabetic Mouse Results in the Impairment of Both T Cell Activation and CTLA-4 Up-Regulation

2000 • 104 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

2003 • 98 citations

Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.

1993 • 97 citations

Plasmid Vaccination with Insulin B Chain Prevents Autoimmune Diabetes in Nonobese Diabetic Mice

2001 • 97 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

Pathways for self-tolerance and the treatment of autoimmune diseases

2001 • 85 citations

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

1997 • 85 citations

Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors

2000 • 84 citations

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

1998 • 84 citations

A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouse

2001 • 81 citations

Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein

1999 • 78 citations

Impaired Plasma Membrane Targeting of Grb2–Murine Son of Sevenless (mSOS) Complex and Differential Activation of the Fyn–T Cell Receptor (TCR)-ζ–Cbl Pathway Mediate T Cell Hyporesponsiveness in Autoimmune Nonobese Diabetic Mice

1997 • 70 citations

Intramuscular administration of expression plasmids encoding interferon-γ receptor/IgG1 or IL-4/IgG1 chimeric proteins protects from autoimmunity

1999 • 64 citations

Plasmid DNAs Encoding Insulin and Glutamic Acid Decarboxylase 65 Have Distinct Effects on the Progression of Autoimmune Diabetes in Nonobese Diabetic Mice

2001 • 63 citations

T Cell Response to Preproinsulin I and II in the Nonobese Diabetic Mouse

2002 • 60 citations

Immunization with DNA Encoding an Immunodominant Peptide of Insulin Prevents Diabetes in NOD Mice

2001 • 55 citations

Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain.

1995 • 52 citations

Immunoinhibitory DNA Vaccine Protects Against Autoimmune Diabetes Through cDNA Encoding a Selective CTLA-4 (CD152) Ligand

2002 • 49 citations

Autoimmune diabetes results from genetic defects manifest by antigen presenting cells

1993 • 48 citations

Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice

2002 • 48 citations

Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity

2002 • 48 citations

Requirement for a Complex Array of Costimulators in the Negative Selection of Autoreactive Thymocytes In Vivo

2001 • 46 citations

Approaches to Type 1 Diabetes Prevention by Intervention in Cytokine Immunoregulatory Circuits

2001 • 44 citations

Effect of Oral and Intravenous Insulin and Glutamic Acid Decarboxylase in NOD Mice

1997 • 34 citations

CD40 Ligand Functions Non-Cell Autonomously to Promote Deletion of Self-Reactive Thymocytes

2002 • 32 citations

DNA Vaccination in the Treatment of Autoimmune Disease

2000 • 24 citations

Comparative Study of the Protective Effect Afforded by Intravenous Administration of Bovine or Ovine Insulin to Young NOD Mice

1995 • 23 citations

Proinsulin 2 Knockout NOD Mice

2002 • 20 citations

Cytotoxic T Lymphocyte Antigen 4 (CD152) Regulates Self-Reactive T cells in BALB/c but not in the Autoimmune NOD Mouse

2000 • 17 citations

Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA4\CD28:B7 interaction by site-directed mutagenesis: a novel structural model of the binding site

1998 • 12 citations

Cytokine and immunosuppressive therapies of type 1 diabetes mellitus

2002 • 6 citations

The role of CD154 (CD40-ligand) in costimulation

2001 • 5 citations